The impact of clinical parameters on progression-free survival of non-small cell lung cancer patients harboring EGFR-mutations receiving first-line EGFR-tyrosine …

YM Chen, CH Lai, HC Chang, TY Chao, CC Tseng… - Lung cancer, 2016 - Elsevier
… several clinical parameters might differentially affect treatment response in patients receiving
EGFR-… role of several clinical parameters in EGFR-mutant, NSCLC patients who received …

Clinical impact of amphiregulin expression in patients with epidermal growth factor receptor (EGFR) wild‐type nonsmall cell lung cancer treated with EGFRtyrosine …

MH Chang, HK Ahn, J Lee, CK Jung, YL Choi… - Cancer, 2011 - Wiley Online Library
EGFR mutation rate is attributed to the enriched patient population, which had favorable
clinical parameters. … patients with WT EGFR-positive NSCLC may obtain a clinical benefit from …

Clinical and molecular features of epidermal growth factor receptor (EGFR) mutation positive non-small-cell lung cancer (NSCLC) patients treated with tyrosine kinase …

P Bironzo, ML Reale, T Sperone, F Tabbò, A Caglio… - Cancers, 2021 - mdpi.com
EGFR-TKIs efficacy in advanced EGFR mutated NSCLC and could be associated with
worse prognosis. Using a clinical … in 106 consecutive patients treated with front-line EGFR-TKIs. …

Clinical significance of serum EGFR gene mutation and serum tumor markers in predicting tyrosine kinase inhibitor efficacy in lung adenocarcinoma

LX Feng, J Wang, Z Yu, SA Song, WX Zhai… - Clinical and …, 2019 - Springer
… The drug tyrosine kinase inhibitor (TKI) acts as a competitive inhibitor of … EGFR-TK region
of tyrosine kinases. TKI can also be used as a tyrosine analog to block the activity of tyrosine

… -based growth tumor kinetics as a prognostic biomarker for patients with EGFR mutant lung adenocarcinoma undergoing EGFR tyrosine kinase inhibitor therapy: a …

JH Lee, HY Lee, MJ Ahn, K Park, JS Ahn, JM Sun… - Cancer Imaging, 2016 - Springer
… We acquired our patient data from a clinical trial of EGFR TKIs for … with activated EGFR
mutations who received EGFR-TKI therapy … In conclusion, early radiologic parameters of tumors …

Clinical modes of EGFR tyrosine kinase inhibitor failure and subsequent management in advanced non-small cell lung cancer

JJ Yang, HJ Chen, HH Yan, XC Zhang, Q Zhou, J Su… - Lung cancer, 2013 - Elsevier
… There is no published overview of epidermal growth factor receptor (EGFR) tyrosine kinase
… the diversity of EGFR-TKI failure, and to investigate the usefulness of clinical modes in …

Clinical predictors of response to EGFR-tyrosine kinase inhibitors in EGFR-mutated non-small cell lung cancer: a real-world multicentric cohort analysis from India

A Garg, U Batra, P Choudhary, D Jain… - Current Problems in …, 2020 - Elsevier
… (EGFR) has been a major step in therapeutic advancements in lung cancer. However, the
response to tyrosine … Methods: As part of a retrospective analysis, patients with EGFR mutated …

[HTML][HTML] Early prediction of response to tyrosine kinase inhibitors by quantification of EGFR mutations in plasma of NSCLC patients

A Marchetti, JF Palma, L Felicioni, TM De Pas… - Journal of Thoracic …, 2015 - Elsevier
EGFR in plasma DNA in the first days of treatment may represent an early predictive parameter
of clinical … With the strong correlation between EGFR SQI in plasma and clinical outcome, …

… -dimer concentration and an occurrence of skin rash as iatrogenic events and complementary predictors of survival in lung cancer patients treated with EGFR tyrosine …

M Zaborowska-Szmit, DM Kowalski, A Piórek… - Pharmacological …, 2016 - Elsevier
clinical parameters as factors determining PFS in patients with NSCLC treated with EGFR
seem to be very clinically valuable because the decline in the concentration of D-dimer on anti-…

Phosphorylated EGFR expression may predict outcome of EGFR-TKIs therapy for the advanced NSCLC patients with wild-type EGFR

F Wang, S Wang, Z Wang, J Duan, T An, J Zhao… - … Experimental & Clinical …, 2012 - Springer
EGFR gene constitutively enhanced EGFR tyrosine kinase activity and receptor
autophosphorylation[23–25]. This suggests that regulation of receptor's tyrosineparameters