… showing that systemic PCSK9 deficiency results in heart failure with preserved ejection
fraction, a finding independent of the modulation of LDL receptor and of circulating PCSK9. This …

… ejection fraction (HFpEF) in mice. To translate their findings in humans, the authors used
the well-categorized R46L PCSK9 genetic variant as a proxy for PCSK9 … that PCSK9-deficient …

… the involvement of circulating PCSK9 in the development of HFpEF … ejection fraction
compared to R46R BMI-matched controls. Conclusions: These data suggest that PCSK9 deficiency …

… This study unravels and comprehensively characterizes an unexpected cardiac phenotype
suggestive of heart failure with preserved ejection fraction associated with PCSK9 deficiency …

… ejection fraction [55]. In another study, there was a trend, though not significant, in which serum
PCSK9 … salt-insensitive hypertension [114], PCSK9 deficiency contributes to a modest but …

… When PCSK9 is deficient, researchers also attested that PCSK9 can rewire cardiac … heart
failure with preserved ejection fraction [22]. All these evidences indicate that PCSK9 is closely …

… Results: Pcsk9 KO displays a reduced running endurance associated with … of heart failure
with preserved ejection fraction (HFpEF). PCSK9 deficiency is affecting cardiac metabolism …

… the function of PCSK9 specifically in the heart by generating and analysing mice with
cardiomyocyte-specific Pcsk9 deficiency (CM-Pcsk9 −/− mice) and by silencing Pcsk9 acutely in a …

… Methods: We analysed PCSK9 KO as well as wildtype (WT) … Results: Our study revealed,
that PCSK9 KO itself did not … ), stroke volume (SV) or ejection fraction (EF) compared to WT mice…

… resulted in prompt PCSK9 expression and autophagy … PCSK9 during hypoxia induced, and
treatment with PCSK9 siRNA reduced, autophagy suggesting a possible role of PCSK9 in the …