Efficacy and safety of apixaban compared with aspirin in the elderly: a subgroup analysis from the AVERROES trial

KH Ng, O Shestakovska, SJ Connolly… - Age and …, 2016 - academic.oup.com
… We report the effects of apixaban versus acetylsalicylic acid (ASA) in older patients (≥75
years … , it difficult to justify the use of aspirin in elderly patients with AF, if apixaban is available. …

Anticoagulants for stroke prevention in atrial fibrillation in elderly patients

A Schäfer, U Flierl, D Berliner, J Bauersachs - Cardiovascular drugs and …, 2020 - Springer
… In summary, it seems reasonable to use NOACs for elderly patients with AF instead … elderly
patients compared with VKA on apixaban followed by edoxaban, whereas in elderly patients, …

Effect of apixaban versus warfarin use on health care resource utilization and costs among elderly patients with nonvalvular atrial fibrillation

S Deitelzweig, X Luo, K Gupta, J Trocio… - Journal of Managed …, 2017 - jmcp.org
… versus warfarin on HCRU and costs among elderly NVAF patients. The results of the study
show that elderly NVAF patients who initiated apixaban significantly differed in many patient

Clinical implications of assessment of apixaban levels in elderly atrial fibrillation patients: J-ELD AF registry sub-cohort analysis

S Suzuki, T Yamashita, M Akao, K Okumura… - European Journal of …, 2020 - Springer
… dose (in the present study, ≥86 ng/mL) could be a tool for identifying those with a high risk
of bleeding among elderly patients with AF, although a high Api-AXA value itself does not …

Effects of age and sex on the single-dose pharmacokinetics and pharmacodynamics of apixaban

CE Frost, Y Song, A Shenker, J Wang, YC Barrett… - Clinical …, 2015 - Springer
… The apixaban CL R tended to be lower in elderly subjects (0.45 L/h) than in young subjects
(0.63 L/h) and lower in female subjects (0.46 L/h) than in male subjects (0.62 L/h); these …

A multicenter prospective cohort study to investigate the effectiveness and safety of apixaban in Japanese elderly atrial fibrillation patients (J‐ELD AF Registry)

K Okumura, T Yamashita, S Suzuki, M Akao… - Clinical …, 2020 - Wiley Online Library
… of the on-label reduced dose apixaban in >1700 elderly AF patients, supporting the conclusions
shown in the ARISTOTLE subanalysis for the elderly patients.14 Since underdosing of …

[PDF][PDF] Efficacy and safety of oral anticoagulation in elderly patients with atrial fibrillation.

I Cavallari, G Patti - Anatolian Journal of Cardiology/Anadolu …, 2018 - jag.journalagent.com
… However, data from phase III clinical trials on atrial fibrillation overall indicate that apixaban
and edoxaban in elderly patients are associated with the highest reduction of extracranial …

Effectiveness and safety of oral anticoagulants in elderly patients with atrial fibrillation

OCW Rutherford, C Jonasson, W Ghanima… - Heart, 2022 - heart.bmj.com
… in elderly patients with atrial fibrillation (AF) in a real-world population. Methods We identified
all anticoagulant-naive initiators of warfarin, dabigatran, rivaroxaban and apixaban for the …

[HTML][HTML] Efficacy and safety of novel anticoagulants in the elderly

N Karamichalakis, S Georgopoulos… - Journal of geriatric …, 2016 - ncbi.nlm.nih.gov
… studies with elderly participants have shown that apixaban is … safety of apixaban is consistent
among various groups of patients, … Elderly patients with AF and VTE are at elevated risk of …

Effectiveness and safety of oral anticoagulants in older patients with atrial fibrillation: a systematic review and meta-analysis

M Grymonprez, S Steurbaut, TL De Backer… - Frontiers in …, 2020 - frontiersin.org
… was observed in older AF patients, as opposed to lower risks for apixaban and edoxaban. …
of NOACs versus VKAs in elderly atrial fibrillation patients ≥75 years old. Api 5/2.5, …