Interleukin1 blockade inhibits the acute inflammatory response in patients with ST‐segment–elevation myocardial infarction

A Abbate, CR Trankle, LF Buckley… - Journal of the …, 2020 - Am Heart Assoc
… –elevation myocardial infarction is associated with an intense acute inflammatory response
and risk of heart failure. We tested whether interleukin1 … –elevation myocardial infarction (…

Early interleukin-1 receptor antagonist elevation in patients with acute myocardial infarction

G Patti, A D'Ambrosio, S Mega, G Giorgi… - Journal of the American …, 2004 - jacc.org
… evaluate interleukin-1 receptor antagonist (IL-1Ra) levels in patients with ST-segment elevation
acute myocardial infarction … by comparison with common markers of myocardial necrosis. …

Antiarrhythmic effects of interleukin 1 inhibition after myocardial infarction

NM De Jesus, L Wang, J Lai, RR Rigor, SDF Stuart… - Heart rhythm, 2017 - Elsevier
Interleukin 1β (IL-1β) is a key regulator of the inflammatory response after myocardial infarction
(MI) … Elevated levels of IL-1β are associated with adverse remodeling, and inhibition of IL-…

Interleukin1 receptor antagonist levels correlate with extent of myocardial loss in patients with acute myocardial infarction

G Patti, S Mega, V Pasceri, A Nusca… - … Indexed and Peer …, 2005 - Wiley Online Library
Interleukin-1Ra may also represent a useful diagnostic tool in patients with acute
myocardial infarction (MI), since its levels rise early and precede release of markers of myocardial …

[HTML][HTML] Effect of interleukin-1 blockade with anakinra on leukocyte count in patients with ST-segment elevation acute myocardial infarction

MG Del Buono, JI Damonte, CR Trankle, D Kadariya… - Scientific Reports, 2022 - nature.com
… with ST elevation myocardial infarction (STEMI) and portends a poor prognosis. Interleukin
1-β … (recombinant human interleukin-1 [IL-1] receptor antagonist) suppresses leukocytosis in …

Effects of interleukin-1 on cardiac fibroblast function: relevance to post-myocardial infarction remodelling

NA Turner - Vascular Pharmacology, 2014 - Elsevier
… of 10 patients with acute myocardial infarction with ST-segment elevation (STEMI), Anakinra
… of symptoms appeared to have beneficial effects on cardiac remodelling [1]. However, in the …

Interleukin-1 blockade with anakinra and heart failure following ST-segment elevation myocardial infarction: results from a pooled analysis of the VCUART clinical …

A Abbate, GF Wohlford, MG Del Buono… - European Heart …, 2022 - academic.oup.com
… ST-segment elevation myocardial infarction (STEMI) is associated with an intense acute …
In this study, we sought to evaluate the effect of anakinra, a recombinant interleukin-1

Interleukin-1 blockade in cardiovascular diseases: a clinical update

LF Buckley, A Abbate - European heart journal, 2018 - academic.oup.com
… non-ST-segment elevation myocardial infarction (NSTEMI), IL-1 blockade with anakinra also
reduced CRP levels at 7 days after non-ST-segment elevation acute coronary syndrome but …

Effects of interleukin-1 blockade with anakinra on adverse cardiac remodeling and heart failure after acute myocardial infarction [from the Virginia Commonwealth …

A Abbate, BW Van Tassell, G Biondi-Zoccai… - The American journal of …, 2013 - Elsevier
… In conclusion, interleukin-1 blockade with anakinra blunted … ST-segment elevation acute
myocardial infarction. Although it … Acute myocardial infarction with ST-segment elevation (STEMI…

Comparative safety of interleukin-1 blockade with anakinra in patients with ST-segment elevation acute myocardial infarction (from the VCU-ART and VCU-ART2 pilot …

A Abbate, MC Kontos, NA Abouzaki… - The American journal of …, 2015 - Elsevier
elevation myocardial infarction (STEMI5, 6), non–ST-segment elevation myocardial infarction
(… , 11 It is, however, unknown whether IL-1 activity is a modifiable factor leading to improved …