Upholding a role for EMT in pancreatic cancer metastasis

NM Aiello, T Brabletz, Y Kang, MA Nieto, RA Weinberg… - Nature, 2017 - nature.com
… network that defines and orchestrates EMT in pancreatic carcinomas, we believe that the …
versions of the EMT program and therefore to completely suppress activation of EMT. Hence…

EMT and treatment resistance in pancreatic cancer

N Gaianigo, D Melisi, C Carbone - Cancers, 2017 - mdpi.com
… we summarize the role of EMT in the context of drug resistance and metastasis in PC, with a
… However, the role of the microbiome in EMT induction in pancreatic cancer cells is plausible …

[HTML][HTML] Pancreatic cancer stem cells and EMT in drug resistance and metastasis

FH Sarkar, Y Li, Z Wang, D Kong - Minerva chirurgica, 2009 - ncbi.nlm.nih.gov
EMT has been shown to be important on conferring drug resistance characteristics to cancer
… We have reported that EMT in pancreatic cancer influences the sensitivity of cancer cells to …

[HTML][HTML] The role of EMT in pancreatic cancer progression

Q Wu, L Miele, FH Sarkar, Z Wang - Pancreatic disorders & therapy, 2012 - ncbi.nlm.nih.gov
… In summary, EMT has been found to play critical roles in the control of tumor invasion,
metastasis and drug resistance in PCa. Several factors, cytokines and cellular signaling pathways …

The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer

AM Krebs, J Mitschke, M Lasierra Losada… - Nature cell …, 2017 - nature.com
… role for the EMT-TF Zeb1 in the in vivo progression of pancreatic cancer from early precursor
lesions towards metastasis. Genetic depletion of Zeb1 in the pancreas reduces formation of …

[HTML][HTML] Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer

MV Recouvreux, MR Moldenhauer… - Journal of Experimental …, 2020 - rupress.org
EMT) in pancreatic ductal adenocarcinoma (PDAC) cells. Mechanistically, we demonstrate
that glutamine deficiency regulates EMT through the up-regulation of the EMT … –induced EMT, …

[HTML][HTML] EMT and dissemination precede pancreatic tumor formation

AD Rhim, ET Mirek, NM Aiello, A Maitra, JM Bailey… - Cell, 2012 - cell.com
… breast cancer, have given rise to two major metastasis paradigms. The classical model treats
metastasis … serve as independent predictors of mortality in patients with pancreatic cancer ( …

The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer

P Zhou, B Li, F Liu, M Zhang, Q Wang, Y Liu, Y Yao… - Molecular cancer, 2017 - Springer
… role of EMT and PCSCs in tumor progression, metastasis and … in treatment resistance of
pancreatic cancer. These findings … controlling EMT and cancer stem cells in pancreatic cancer

Molecular profile of metastasis, cell plasticity and EMT in pancreatic cancer: a pre-clinical connection to aggressiveness and drug resistance

Z Guo, M Ashrafizadeh, W Zhang, R Zou… - Cancer and metastasis …, 2024 - Springer
… of cancer cells has been related to the development of drug resistance. Metastasis of pancreatic
cancer (PC… The stimulation of EMT in PC cells occurs as a result of changes in molecular …

Epithelial‐mesenchymal transition in pancreatic cancer: a review

S Wang, S Huang, YL Sun - BioMed research international, 2017 - Wiley Online Library
… the roles of EMT in the dissemination and metastasis of pancreaticEMT during the metastatic
process of pancreatic cancer. Circulating tumor cells (CTCs) or circulating pancreatic cells (…