Integrating endocannabinoid signaling and cannabinoids into the biology and treatment of posttraumatic stress disorder

MN Hill, P Campolongo, R Yehuda… - …, 2018 - nature.com
… Finally, we propose that a state of endocannabinoid deficiency could represent a stress
susceptibility endophenotype predisposing to the development of trauma-related …

Endocannabinoid signaling in psychiatric disorders: a review of positron emission tomography studies

ME Sloan, CW Grant, JL Gowin… - Acta Pharmacologica …, 2019 - nature.com
… with anorexia nervosa and post-traumatic stress disorder, but limited data have been …
alterations in endocannabinoid signaling are present in a range of psychiatric disorders. Although …

Regulation of endocannabinoid signaling by stress: implications for stress-related affective disorders

BB Gorzalka, MN Hill, CJ Hillard - Neuroscience & Biobehavioral Reviews, 2008 - Elsevier
… by maladaptive stress coping. In this review, we discuss the evidence demonstrating that the
endocannabinoid system is affected by and can oppose the effects of prolonged stress and, …

[HTML][HTML] Targeting the endocannabinoid system in the treatment of posttraumatic stress disorder: A promising case of preclinical-clinical translation?

LM Mayo, CA Rabinak, MN Hill, M Heilig - Biological psychiatry, 2022 - Elsevier
… Failure to extinguish traumatic memories is a core symptom of posttraumatic stress disorder,
suggesting that potentiating eCB signaling may have a therapeutic potential in this condition…

Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the World Trade Center attacks

MN Hill, LM Bierer, I Makotkine, JA Golier… - …, 2013 - Elsevier
Endocannabinoid (eCB) signaling has been identified as a modulator of adaptation to stress,
and is integral to basal and stress… development of post-traumatic stress disorder (PTSD). To …

Endocannabinoid signalling modulates susceptibility to traumatic stress exposure

RJ Bluett, R Báldi, A Haymer, AD Gaulden… - Nature …, 2017 - nature.com
… of affective disorders including major depression and posttraumatic stress disorder. …
stress could have broad implications for the treatment and prevention of mood and anxiety …

Stress regulates endocannabinoid-CB1 receptor signaling

CJ Hillard - Seminars in immunology, 2014 - Elsevier
… Deficiency of CB1 receptor signaling is … receptor-endocannabinoid signaling is activated
by stress and functions to buffer or dampen the behavioral and endocrine effects of acute stress. …

Endocannabinoid signaling and epigenetics modifications in the neurobiology of stress-related disorders

AA Coelho, S Lima-Bastos, PH Gobira… - … Signaling, 2023 - portlandpress.com
Stress exposure is associated with psychiatric conditions, such as depression, … stress
disorder (PTSD). It is also a vulnerability factor to developing or reinstating substance use disorder. …

A critical role for prefrontocortical endocannabinoid signaling in the regulation of stress and emotional behavior

RJ McLaughlin, MN Hill, BB Gorzalka - Neuroscience & Biobehavioral …, 2014 - Elsevier
… flow and neuronal activity have been identified in a variety of anxiety disorders, particularly
post-traumatic stress disorder and social anxiety disorder (Freitas-Ferrari et al., 2010), and …

… of enhancing endocannabinoid signaling and blocking corticotrophin releasing factor receptor in the amygdala and hippocampus on the consolidation of a stressful …

N Aisenberg, L Serova, EL Sabban, I Akirav - European …, 2017 - Elsevier
… Exposure to an excessive or an uncontrolled stress is a major factor associated with various
diseases including post-traumatic stress disorder (PTSD). The consequences of exposure to …