… therapy for breast cancer is the first targeted therapy used in any type of cancer. It was used
successfully without a known target … Subsequently, it was found that endocrine therapy was …

… An algorithm for endocrine treatment and targeted therapy for HR-positive, HER2-negative …
Algorithm for endocrine treatment and targeted therapy for HR-positive, HER2-negative MBC. …

… of endocrine treatment – … endocrine treatments can produce responses in many patients,
demonstrating that fulvestrant does not lead to cross-resistance with other endocrine therapies. …

… all available data on target therapy combinations with endocrine therapy for both the early …
previously exposed to endocrine treatment and excluded patients who had been treated with …

… This confirmed that for pre-menopausal patients, on the premise of ovarian function
suppression, ribociclib combined with endocrine treatment as first-line therapy could also achieve …

… The true goal will be to perform an overall genotyping of each tumor, thus predicting the
impact of combined targeted therapies in the context of a particular constellation of mutant genes…

… Chemotherapy with or without targeted therapy, or endocrine therapy (if hormone
receptor–positive [HR-positive]) may be offered (Type: evidence-based; benefits outweigh harms; …

… is currently approved by the US Food and Drug Administration for treatment in the … for
targeting endocrine cancer signaling pathways and provide a paradigm for treatment of endocrine …

… endocrine or anti-HER2 therapy resistance. Moreover, preclinical data support the idea that
PI3K inhibitors and CDK4/6 could be an attractive target … studies testing targeted therapies in …

… resistance represents a significant challenge in the treatment … co-targeting these pathways
can restore endocrine sensitivity… to improve the efficacy of endocrine treatment in ER-positive …