Circadian clock protein BMAL1 broadly influences autophagy and endolysosomal function in astrocytes
CA McKee, AJ Polino, MW King… - Proceedings of the …, 2023 - National Acad Sciences
… lysosomal pathways identified in our GO analysis and our measures of increased lysosomal
markers and endolysosomal … expression of the critical endolysosomal regulator TFEB or its …
markers and endolysosomal … expression of the critical endolysosomal regulator TFEB or its …
Nanoplastics exposure disrupts circadian rhythm associated with dysfunction of the endolysosomal pathway and autophagy in Caenorhabditis elegans
CW Yu, YC Wu, VHC Liao - Journal of Hazardous Materials, 2023 - Elsevier
… To understand the link of between NPs toxicity and circadian rhythms, this study aims to
investigate the possible relationship between circadian rhythm disruption and endocytosis and …
investigate the possible relationship between circadian rhythm disruption and endocytosis and …
Circadian autophagy rhythm: a link between clock and metabolism?
D Ma, S Li, MM Molusky, JD Lin - Trends in Endocrinology & Metabolism, 2012 - cell.com
… metabolism in mammals exhibits a strong diurnal rhythm that aligns with the body clock. …
As a consequence, the activities of many metabolic pathways are restricted not only to specific …
As a consequence, the activities of many metabolic pathways are restricted not only to specific …
The biological clock and the molecular basis of lysosomal storage diseases
G Mazzoccoli, T Mazza, M Vinciguerra… - JIMD Reports, Volume …, 2015 - Springer
… A gene necessary for circadian clock function in Drosophila melanogaster is Timeless (Tim), …
driven by the biological clock, so that inflammatory signaling pathways and immune-…
driven by the biological clock, so that inflammatory signaling pathways and immune-…
Reciprocal regulation of chaperone-mediated autophagy and the circadian clock
… Disruption of this circadian clock/CMA axis may be responsible for both pathways … We
analysed proteasome and lysosomal degradation of clock elements in liver under physiological …
analysed proteasome and lysosomal degradation of clock elements in liver under physiological …
Rheostatic balance of circadian rhythm and autophagy in metabolism and disease
X Wang, Z Xu, Y Cai, S Zeng, B Peng, X Ren… - Frontiers in Cell and …, 2020 - frontiersin.org
… Genes and pathways involved in the circadian rhythm regulation of autophagy. … ARN5187
was demonstrated to have the ability to block lysosomal function, disrupt the autophagy …
was demonstrated to have the ability to block lysosomal function, disrupt the autophagy …
Autophagic degradation of the circadian clock regulator promotes ferroptosis
… to as autophagy) involves a lysosomal degradation pathway and plays a context-dependent …
the selective autophagic degradation of the circadian clock regulator ARNTL/BMAL1, …
the selective autophagic degradation of the circadian clock regulator ARNTL/BMAL1, …
Cognitive impairment and dementia: gaining insight through circadian clock gene pathways
K Maiese - Biomolecules, 2021 - mdpi.com
… Microautophagy leads to lysosomal membrane invagination such that components of the cell
… cytosolic chaperones to move components of the cytoplasm across lysosomal membranes. …
… cytosolic chaperones to move components of the cytoplasm across lysosomal membranes. …
The circadian rhythm in intervertebral disc degeneration: an autophagy connection
TW Zhang, ZF Li, J Dong, LB Jiang - Experimental & molecular …, 2020 - nature.com
… Some upstream factors and downstream pathways that interact with CR in IVDs have also
… , REV-ERBα, and Cry1 are lysosomal targets, and the selective autophagic degradation of …
… , REV-ERBα, and Cry1 are lysosomal targets, and the selective autophagic degradation of …
[PDF][PDF] The Biological Clock and the Molecular Basis of Lysosomal Storage Diseases
MVS Castellana - researchgate.net
… A gene necessary for circadian clock function in Drosophila melanogaster is Timeless (Tim), …
driven by the biological clock, so that inflammatory signaling pathways and immune-…
driven by the biological clock, so that inflammatory signaling pathways and immune-…
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