… in cell death, whether apoptotic or necrotic, mediated by the ATF4/CHOP axis. CHOP induces
the transcription of endoplasmic reticulum … This may participate in cell death in vitro and in …

… by endoplasmic reticulum (ER) stress are depicted, and some connections to the cell death
… 1 (IRE1a), PRKR-like endoplasmic reticulum kinase (PERK) and activating transcription …

… prolonged, the UPR induces cell death. The cell death pathways collectively triggered by the
… While many details remain unknown, we are beginning to understand how cells determine …

… part) to regulate calcium homeostasis and apoptotic cell death. Here, we review evidence
for the molecular components involved in cell death signaling induced by ER stress. Based on …

… cell death if ER dysfunction is severe or prolonged. The mechanisms by which ER stress
leads to cell death … but little clarity about which specific death effectors dominate in particular …

… The present study was performed to determine whether ER stress-induced cell death requires
… of caspases during ER stress-mediated cell death that is induced by an array of insults. …

… of the endoplasmic reticulum (ER) is critical for numerous aspects of cell physiology. …
or intense ER stress can also trigger programmed cell death, or apoptosis. ER stress and …

… studies indicate that palmitate-induced intracellular responses converge on the mitochondria,
eventually resulting in the release of cytochrome c into the cytosol and apoptotic cell death…

… The UPR might also contribute to FFA-induced β-cell death through upregulation of the …
stress in β-cells, which might play a role in cytokine-induced cell death in type 1 diabetes [ …

… The endoplasmic reticulum (ER) and mitochondria cannot be considered as static structures…
-mitochondria contact sites and Ca 2+ signaling can alter the cell death execution program. …