Regulation of endothelial function by mitochondrial reactive oxygen species

ME Widlansky, DD Gutterman - Antioxidants & redox signaling, 2011 - liebertpub.com
… cell-signaling molecules in the vascular endothelium, where their production, … Mitochondrial
reactive oxygen species appear to regulate important vascular homeostatic functions

Mitochondrial reactive oxygen species and vascular function: less is more

JK Freed, DD Gutterman - … , thrombosis, and vascular biology, 2013 - Am Heart Assoc
… impairs endothelium-dependent vasodilation, producing what is referred to as endothelial
dysfunction… The various sources of oxidative stress within the vascular endothelial cell include …

Mitochondrial reactive oxygen species-mediated signaling in endothelial cells

DX Zhang, DD Gutterman - American Journal of Physiology …, 2007 - journals.physiology.org
vascular endothelialmitochondrial ROS regulate vascular endothelial function, focusing
on major sites of ROS production in endothelial mitochondria, factors modulating mitochondrial

Mitochondria and endothelial function

MA Kluge, JL Fetterman, JA Vita - Circulation research, 2013 - Am Heart Assoc
… in endothelial cells primarily function in signaling … of mitochondrial biology in endothelial
cells, including subcellular location, biogenesis, dynamics, autophagy, reactive oxygen species

Endothelial mitochondria: contributing to vascular function and disease

SM Davidson, MR Duchen - Circulation research, 2007 - Am Heart Assoc
… and the generation of reactive oxygen species and nitric oxide. The mitochondria may also
constitute critical “targets” of oxidative stress, because survival of endothelial cells can be …

Mitochondria, endothelial cell function, and vascular diseases

X Tang, YX Luo, HZ Chen, DP Liu - Frontiers in physiology, 2014 - frontiersin.org
… the generation of reactive oxygen species, the regulation of … functions of mitochondria in
endothelial cells and discuss the roles of mitochondria in endothelial dysfunction and vascular

Mitochondrial mechanisms of endothelial dysfunction

A Szewczyk, W Jarmuszkiewicz, A Koziel… - Pharmacological …, 2015 - Springer
… system by stimulation of excessive generation of reactive oxygen species (… and mitochondrial
respiratory chain complexes. Modulation of mitochondrial energy metabolism in endothelial

Coronary endothelial dysfunction and mitochondrial reactive oxygen species in type 2 diabetic mice

YE Cho, A Basu, A Dai, M Heldak… - American Journal of …, 2013 - journals.physiology.org
… In this study we investigate whether and how reactive oxygen species (ROS) in mitochondria
contribute to coronary endothelial dysfunction in type 2 diabetic (T2D) mice. T2D was …

Mitochondrial signaling in the vascular endothelium: beyond reactive oxygen species

AO Kadlec, AM Beyer, K Ait-Aissa… - Basic research in …, 2016 - Springer
… The critical role of the mitochondria in regulating endothelial function is now clear, with
particular attention having been paid to the role of reactive oxygen species (ROS) as signaling …

Functional role of mitochondrial reactive oxygen species in physiology

PR Angelova, AY Abramov - Free radical biology and medicine, 2016 - Elsevier
… – mitochondria produce reactive oxygen species as a by-product of a number of enzymatic
reactions and the production of ATP. Emerging evidence suggests that mitochondrial ROS …