… The single components of the insulin and leptin signalling pathways in the POMC and AgRP
neurons, and their effects on glucose and energy homeostasis, are discussed in more detail …

… Four recent studies addressed this by creating mice in which AgRP neurons, which also …
suggest that AgRP neurons are more essential to feeding and weight gain than is AgRP itself. A …

… Neurons To identify the possible roles of hypothalamic autophagy in regulating energy
balance, we modified autophagy in hypothalamic AgRP neurons. To this end, we assessed food …

… , we showed that the lack of AgRP neurons affects the relative balance between lipid and
carbohydrate metabolism. As a consequence, mice lacking AgRP neurons became obese and …

… AgRP neurons, the undeniable demonstration of their critical role in the control of energy
balance came from the study of AgRP neuron… (DTR) specifically in AgRP neurons (AgRP DTR ), …

… with POMC neurons mediating, indirectly via AgRP neurons, … from AgRP neurons is required
for the regulation of energy … We demonstrate the usefulness of neuron-specific deletion …

… (AgRP). This paper reviews the regulation of the NPY/AgRP neuron in energy homeostasis
… tion to compensatory responses induced by changes in energy balance and body fat stores. …

… Alongside their disparate effects on energy balance, POMC and AgRP neurons are reciprocally
regulated by circulating cues of nutritional state, including the adiposity hormones leptin …

… We discuss how the sensory detection of food or food cues influences AgRP neural … AgRP
neurons transmit a negative valence learning signal when food is not present and how AgRP-…

… Because NPY/Agrp neurons play an important role in transitioning to negative energy balance,
and their excitability was impaired in Agrp-Sirt1 KO mice, we postulated that challenging …