Brain regulation of energy balance and body weight

L Rui - Reviews in Endocrine and Metabolic Disorders, 2013 - Springer
… action of AgRP neurons. AgRP neurons project to the PVH and inhibit PVH neuronal activity
… These inhibitory projections are required for AgRP neurons to stimulate feeding behavior [85…

Hypothalamic and brainstem neuronal circuits controlling homeostatic energy balance

M Schneeberger, R Gomis… - Journal of endocrinology, 2014 - joe.bioscientifica.com
… The actions of ghrelin on food intake and energy balance are mediated by AgRP neurons, …
in the regulation of energy balance where POMC and AgRP neurons send axon projections. …

Agrp-negative arcuate NPY neurons drive feeding under positive energy balance via altering leptin responsiveness in POMC neurons

Y Qi, NJ Lee, CK Ip, R Enriquez, R Tasan, L Zhang… - Cell Metabolism, 2023 - cell.com
… in AGRP neurons may be somewhat compensated for by increased Agrp expression under
negative energy balance. … of NPY neurons in the ARC that do not co-express Agrp and that …

[HTML][HTML] Direct and indirect effects of liraglutide on hypothalamic POMC and NPY/AgRP neurons–Implications for energy balance and glucose control

Z He, Y Gao, L Lieu, S Afrin, J Cao, NJ Michael… - Molecular …, 2019 - Elsevier
neurons is also essential for proper energy balance [26], [27], [28], [29]. Moreover, GLP-1
receptors in POMC neurons … arcuate POMC and NPY/AgRP neuronal activity and contribute to …

[HTML][HTML] PGC-1α expression in murine AgRP neurons regulates food intake and energy balance

JF Gill, J Delezie, G Santos, C Handschin - Molecular metabolism, 2016 - Elsevier
… of various signaling pathways in AgRP neurons and thereby sheds additional light on the
regulation of whole body energy balance by hypothalamic neurons, which are attractive targets …

Effects of hypothalamic neurodegeneration on energy balance

AW Xu, CB Kaelin, GJ Morton, K Ogimoto… - PLoS …, 2005 - journals.plos.org
… weight by Agrp neurons involves compensation by redundant genes, and provide a model
for understanding defects in energy balance associated with aging and neurodegeneration. …

Effects of AgRP inhibition on energy balance and metabolism in rodent models

R Dutia, AJ Kim, M Modes, R Rothlein, JM Shen… - PLoS …, 2013 - journals.plos.org
… of POMC neurons and wide distribution of brain MC-Rs [24]–[28]. In contrast… AgRP neuronal
projections are more limited to brain areas involved with energy balance, making AgRP

The elegance of energy balance: Insight from circuit‐level manipulations

ES Webber, A Bonci, MJ Krashes - Synapse, 2015 - Wiley Online Library
… However, only selective deletion of Grin1 from ARC AgRP neurons (AgRP KO-NMDA )
disrupted energy balance. These animals had markedly lower body weight and fat stores, …

Regulation of substrate utilization and adiposity by Agrp neurons

JP Cavalcanti-de-Albuquerque, J Bober… - Nature …, 2019 - nature.com
… contribution of Agrp neurons to adiposity and weight gain during obesogenic conditions,
we set out to selectively activate Agrp neurons under controlled positive energy balance. We …

POMC neuronal heterogeneity in energy balance and beyond: an integrated view

C Quarta, M Claret, LM Zeltser, KW Williams… - Nature …, 2021 - nature.com
… A second neuronal population co-expressing neuropeptide Y (… (AgRP) is instead activated
by negative energy balance. Following activation, NPY/AgRP neurons inhibit POMC neurons 5…