… and responds to changes in energy balance. It seems that two adjacent groups of cells in
the arcuate nucleus, the Agrp/Npy neurons and the Pomc/Cart neurons, act as the primary site …

… a negative energy state. Based on these observations, we hypothesized a role for AgRP
neuron … to the associated increase in energy expenditure or a state of negative energy balance. …

… that reside in the arcuate region of the hypothalamus integrate hormonal and neurotransmitter
signals to modulate appetite and metabolism and thereby help maintain energy balance ( …

… neurons that coexpress agouti-related peptide (AgRP) and neuropeptide Y (NPY) and the
neurons … Both NPY/AgRP- and POMC-containing neurons project extensively to other key hypo…

… Npy from Agrp neurons (approximately 80% of all Npy neurons) led … energy expenditure
suggesting that NPY in these Npy+/Agrp+ neurons may act to decrease RQ and increase energy …

… AgRP neurons, we looked to unravel their relative temporal role in driving food intake. After
the acute stimulation of AgRP neurons … , and the neuropeptide AgRP, through action on MC4 …

… in the control of energy balance. However, strategies targeting hypothalamic neurons have
failed to … control of neighboring neuron activity, autonomic outflow, glucose metabolism, and …

… energy homeostasis facilitates stability of adipose stores by ensuring that short-term changes
in energy balance … (NPY/Agrp) that has the potential to activate neuronal feeding pathways …

… energy balance (leptin), to alter hypothalamic neuronal function regulating food intake/energy
balance … Two major orexigenic factors, NPY and AGRP, are coexpressed in neurons in the …

… internal metabolic signals of energy balance with external … that maintain neuronal coordination
of energy homeostasis are … for fasting-induced activation of neurons within the arcuate …