Targeted modulation of immune cells and tissues using engineered biomaterials

P Yousefpour, K Ni, DJ Irvine - Nature reviews bioengineering, 2023 - nature.com
Biomaterials can promote specific targeting of immune cell … Here, we review recent advances
in biomaterials-based … , tissue-resident immune cells and immune cells at disease sites. …

Engineering biomaterials to direct innate immunity

RS Oakes, E Froimchuk, CM Jewell - Advanced therapeutics, 2019 - Wiley Online Library
… with adaptive immune cells have informed immune engineered materials that target specific
… that genetically engineering innate immune mechanisms to control cell function can combat …

Engineered biomaterials for in situ tissue regeneration

AK Gaharwar, I Singh, A Khademhosseini - Nature Reviews Materials, 2020 - nature.com
… Depending on the biophysical and biochemical characteristics of the biomaterial, immune
cells … from immune cells helps in the recruitment of endogenous progenitor stem cells. These …

Biomaterial-assisted targeted modulation of immune cells in cancer treatment

H Wang, DJ Mooney - Nature materials, 2018 - nature.com
… These tumour cells can also be engineered to express pro-inflammatory cytokines such as
… exist to achieve broad clinical efficacy with immune cell targeting biomaterials, including non-…

Engineered biomaterials for cancer immunotherapy

L Cai, J Xu, Z Yang, R Tong, Z Dong, C Wang… - MedComm, 2020 - Wiley Online Library
immune cells are recruited to the implant site. Examples of … engineered biomaterials to act
as reservoirs or drug carriers. As described in this review (Table 1), engineered biomaterials

Engineering Biomaterials to Model Immune‐Tumor Interactions In Vitro

A Skirzynska, C Xue, MS Shoichet - Advanced Materials, 2024 - Wiley Online Library
… In this section, we discuss common strategies, summarized in Figure 3, to create
biomaterial-based scaffolds in which immune cells to reside and their subsequent impact on …

Engineering immune tolerance with biomaterials

JM Gammon, CM Jewell - Advanced healthcare materials, 2019 - Wiley Online Library
… of immune signals and promote migration of immune cells. This allows the engineering of a
… intrinsic immunogenic properties of biomaterials modulate immune cell function, and how …

Extracellular matrix‐based strategies for immunomodulatory biomaterials engineering

AT Rowley, RR Nagalla, SW Wang… - Advanced healthcare …, 2019 - Wiley Online Library
… These domains can be functionalized into biomaterials to regulate specific immune cell
functions. This section will focus on engineering ECM-derived peptides into various materials for …

Designing biomaterials with immunomodulatory properties for tissue engineering and regenerative medicine

JI Andorko, CM Jewell - Bioengineering & translational …, 2017 - Wiley Online Library
… applications, the studies in this section highlight opportunities to modulate immune cell
phenotypes by altering the hydrophobicity, charge, or surface chemical functional groups of …

Biomimetic tissue engineering: tuning the immune and inflammatory response to implantable biomaterials

F Taraballi, M Sushnitha, C Tsao… - Advanced …, 2018 - Wiley Online Library
… functionalization is aimed at directly mediating the interactions of the biomaterial with
immune cells, resulting in reduced scar formation or induction of macrophage polarization. …