… of exosome production … clinical applications and prospects of engineered exosomes, as
well as the potential risks and limitations that need to be addressed in exosome engineering, …

… Here, we review the latest clinical developments of exosome biotechnology for … exosome-based
clinical trials. We present current exosome engineering strategies for optimal clinical …

… Therapeutic miRNA mimic or antagonist can be introduced into engineered exosomes
through one of the following ways: (1) co-transfection: producer cells can be co-transfected with …

… Exosomes have great potential for therapeutic applications, but the clinical use is restricted
… Bioengineering of exosomes could be one approach to achieve standardization and …

… cells, have been demonstrated for use in clinical applications [29]. Mesenchymal stem
cell (MSC)-derived exosomes are being extensively investigated to nanomedicines as an …

… This supports the potential clinical application of exosomes as a NIS protein delivery
system for cancer therapy. However, the study was not conducted in vivo, which impairs the …

… of engineering targeting modification of exosomes were reviewed. Furthermore, the potential
value of exosome targeting in clinical application was discussed. Exosomal biogenesis is …

… clinical applications. This review majorly focuses on different methods employed for engineering
exosomes… with the efficacy of engineered exosomes in biomedical applications. Further, …

… Some of these companies already moved on to more promising stage of clinical development
with their own exosome engineering technologies improving efficacy and safety profiles. …

… has led to substantial research aimed at directly modifying or engineering exosomes to …
of applications that employ, modify, or mimic exosome properties for clinical therapeutics. …