Biological characteristics of exosomes and genetically engineered exosomes for the targeted delivery of therapeutic agents

Y Lin, Y Lu, X Li - Journal of Drug Targeting, 2020 - Taylor & Francis
… To improve the delivery of therapeutic messages to cardiac cells, exosomes must be
engineered to modify their cargo and membranes [Citation146]. Therapeutic exosomes could be …

Targeted therapeutic delivery using engineered exosomes and its applications in cardiovascular diseases

D Xitong, Z Xiaorong - Gene, 2016 - Elsevier
… The molecules encapsulated into ILVs are not a random but a selective regulated process,
leading to the profile of cargo molecules inside the exosomes, albeit reflecting the nature and …

[HTML][HTML] Exosome engineering: Current progress in cargo loading and targeted delivery

S Fu, Y Wang, X Xia, JC Zheng - NanoImpact, 2020 - Elsevier
… and functions) of exosome, summarize currently available methodologies for exosomal cargo
loading, review the progress in exosome engineering techniques for targeted delivery, and …

[HTML][HTML] Engineering exosomes for targeted drug delivery

Y Liang, L Duan, J Lu, J Xia - Theranostics, 2021 - ncbi.nlm.nih.gov
engineering of exosomes for targeted drug delivery. In this review, we will introduce the
characteristics of exosomes … Membrane-bound antigen cargo can also be displayed by the C1C2 …

Engineering Approaches for Exosome Cargo Loading and Targeted Delivery: Biological versus Chemical Perspectives

W Ahmed, A Mushtaq, S Ali, N Khan… - … & Engineering, 2024 - ACS Publications
… In addition, we provide an overview of the advances in the use of engineered exosomes for
… of chemically engineered versus bioengineered exosome-mediated target therapies. These …

Biodistribution of exosomes and engineering strategies for targeted delivery of therapeutic exosomes

H Choi, Y Choi, HY Yim, A Mirzaaghasi, JK Yoo… - Tissue engineering and …, 2021 - Springer
… of exosomes. Recent advances accentuate the potential of targeted delivery of engineered
exosomes … and PK of exosomes, as well as exosomal surface engineering technologies for …

Exosomes engineering and their roles as therapy delivery tools, therapeutic targets, and biomarkers

N Kučuk, M Primožič, Ž Knez, M Leitgeb - International journal of …, 2021 - mdpi.com
… ® platform for engineering exosome-based therapeutics production for … of engineering
exosomes, they focus on both cargo … Their focus is mainly on therapeutic RNA as the cargo. The …

Engineered exosomes from different sources for cancer-targeted therapy

M Zhang, S Hu, L Liu, P Dang, Y Liu, Z Sun… - … and targeted therapy, 2023 - nature.com
… decorated with specific targeted molecules, including peptides, can achieve more precise
therapeutic cargo delivery. The miR-HER2 (human epidermal growth factor receptor 2)-loaded …

Encapsulation and assessment of therapeutic cargo in engineered exosomes: a systematic review

Z Chen, M Xiong, J Tian, D Song, S Duan… - Journal of …, 2024 - Springer
engineering exosomes and evaluating their drug delivery effects, and current techniques for
assessing exosome … , pharmacokinetics, and therapeutic outcomes are critically examined. …

FedExosomes: engineering therapeutic biological nanoparticles that truly deliver

ME Marcus, JN Leonard - Pharmaceuticals, 2013 - mdpi.com
exosomes for therapeutic RNA delivery, discuss the potential for engineering exosomes
to … process, which we discuss below when considering specific types of exosomal cargo. …