… review is on antigen-specific tolerance — where immune responses to specific antigens are
… below particularly noteworthy advances in antigen-nonspecific approaches, considering …

… to APCs, ii) biomaterial-mediated control over antigen localization and processing, and iii) …
gies to promote tolerance by altering the trafficking or processing of these self-antigens. …

… antigens, data from preclinical models show that donor-reactive Tregs are more effective
than polyclonal Tregs in promoting transplant tolerance (6)… or chimeric antigen receptors (CAR) …

… Here, we review cell and protein engineering-based approaches that aim to target different
… targeted antigen-specificity using transgenic T cell receptors or chimeric antigen receptors. …

… or tolerance is influenced by the form in which self-antigens … immunological tolerance by
controlling the density of self-antigen … scavenger receptors involved in tolerance. Treatment with …

… antigens to the correct immunological address could induce this desirable immune phenotype.
… of a broadly applicable approach for inducing antigen-specific tolerance to protein-based …

… Because antigen-presenting cells are tolerogenic when they … antigen under non-inflammatory
conditions, the manipulation of antigen presentation may induce antigen-specific tolerance…

… consisting ofa recombinantflagellin challenge antigen and a murine … whole antigens by
selecting epitopes for either tolerance or … Protein engineering strategies have been used to create …

… tolerance (29), and introduction of surrogate high-affinity T cell receptors into T cells to target
cancer-associated antigens (… designed to break tolerance to weakly antigenic peptides. Our …

… genetic engineering to permit expression of a CAR in Tcons and Tregs that bind antibodies
… homing of T cells expressing mAbCAR to specific antigens and cells. We used the mAbCAR …