[HTML][HTML] Graft engineering and adoptive immunotherapy: new approaches to promote immune tolerance after hematopoietic stem cell transplantation

A Bertaina, MG Roncarolo - Frontiers in immunology, 2019 - frontiersin.org
… Current post-HSCT cell therapy approaches designed to induce tolerance and … antigen
receptor (CAR). In the present review, we describe the most recent advances in graft engineering

How do monoclonal antibodies induce tolerance? A role for infectious tolerance?

H Waldmann, S Cobbold - Annual review of immunology, 1998 - annualreviews.org
… suppression and infectious tolerance. In these models, T cells that have never been
exposed to CD4 antibodies become tolerant to grafted antigens by experiencing antigen in the …

Therapeutic T cell engineering

M Sadelain, I Rivière, S Riddell - Nature, 2017 - nature.com
… utilizes physiological antigen recognition and T cell activation to generate antigen-specific T
… The other realm is that of autoimmunity and transplantation tolerance 170 . CAR T cells can …

Harnessing the liver to induce antigen-specific immune tolerance

C Gottwick, A Carambia, J Herkel - Seminars in Immunopathology, 2022 - Springer
… facilitates interactions between liver-resident antigen-presenting cells and lymphocytes passing
… immune tolerance, and review present approaches to harness liver tolerance for antigen-…

Do Treg Speed Up with CARs? Chimeric Antigen Receptor Treg Engineered to Induce Transplant Tolerance

M Kaljanac, H Abken - Transplantation, 2023 - journals.lww.com
… redirected Treg for inducing antigen-specific tolerance in solid organ transplantation in …
engineering Treg with a chimeric antigen receptor (CAR) that conveys both pre defined antigen

Initiation of immune tolerancecontrolled HIV gp41 neutralizing B cell lineages

R Zhang, L Verkoczy, K Wiehe, S Munir Alam… - Science translational …, 2016 - science.org
… autologous neutralizing antibodies (5) … tolerance deletion and anergy (20–23), but the
question of whether the germline UA antibodies of MPER bnAbs are also controlled by tolerance

[HTML][HTML] Persistence of antigen is required to maintain transplantation tolerance induced by genetic modification of bone marrow stem cells

C Tian, J Bagley, J Iacomini - American journal of transplantation, 2006 - Elsevier
… , we have explored using genetic engineering of autologous hematopoietic stem cells (…
method to induce immunological tolerance. Tolerance to a variety of antigens can be achieved by …

PEGylation enables subcutaneously administered nanoparticles to induce antigen-specific immune tolerance

PY Li, F Bearoff, P Zhu, Z Fan, Y Zhu, M Fan… - Journal of controlled …, 2021 - Elsevier
… its focus towards inducing antigen-specific tolerance, in which the immune system is trained
to recognize a specific antigen as “safe”, … Engineering immune tolerance with biomaterials …

Controlled delivery of single or multiple antigens in tolerogenic nanoparticles using peptide-polymer bioconjugates

RM Pearson, LM Casey, KR Hughes, LZ Wang… - Molecular Therapy, 2017 - cell.com
… Polymeric nanoparticles (NPs) have demonstrated their potential to induce antigen (Ag)-specific
immunological tolerance in multiple immune models and are at various stages of …

The induction of cell-mediated immunity and tolerance with protein antigens coupled to syngeneic lymphoid cells.

SD Miller, RP Wetzig, HN Claman - The Journal of experimental …, 1979 - rupress.org
… In the second method, antigen-modified cells … antigen 7 d after antigen-CFA or 6 d after
antigen-modified lymphoid cells (LC). Ear thickness was quantitated using a Mitutoya engineer's