An engineering study on the enhanced control and operation of continuous manufacturing of pharmaceutical tablets via roller compaction

R Singh, M Ierapetritou, R Ramachandran - International journal of …, 2012 - Elsevier
… -wide control strategy for an integrated continuous pharmaceutical tablet manufacturing
process via … The designed control system consists of five cascade control loops and three single …

An enhanced quality evaluation system for continuous manufacturing processes, part 1: theory

KJ Dooley, SG Kapoor - 1990 - asmedigitalcollection.asme.org
Manufacturing Processes, Part 1: Theory A quality evaluation system is presented which
gives enhanced information about the nature of quality changes in continuous manufacturing

Model Predictive Control Strategies for Continuous Manufacturing Processes

I Nascu, NA Diangelakis, M Șușcă, V Mihaly… - Computer Aided …, 2024 - Elsevier
… Motivated by the need for cost-effectiveness enhanced sustainability, reliability, and the …
manufacturing technology, continuous manufacturing has started to replace batch manufacturing

Modernizing pharmaceutical manufacturing: from batch to continuous production

SL Lee, TF O'Connor, X Yang, CN Cruz… - Journal of …, 2015 - Springer
… This article summarizes the potential advantages of continuous manufacturing for pharmaceutical
… provides an opportunity to utilize this enhanced product and process understanding to …

Process analytical technologies and self-optimization algorithms in automated pharmaceutical continuous manufacturing

P Liu, H Jin, Y Chen, D Wang, H Yan, M Wu… - Chinese Chemical …, 2024 - Elsevier
… to continuous manufacturing. While the revolution to continuous and automated manufacturing
… distribution in real time, achieving enhanced control over the polymerization process. The …

Continuous manufacturing in pharmaceutical process development and manufacturing

CL Burcham, AJ Florence… - Annual review of …, 2018 - annualreviews.org
… use of continuous processing for the manufacture of new … manufacturing platforms, and
improved product quality assurance. The transformation from batch to continuous manufacturing

Performance enhancement of a manufacturing industry by using continuous improvement strategies–a case study

J Singh, H Singh - International Journal of Productivity and …, 2014 - inderscienceonline.com
continuous improvement strategies. This paper highlights the contributions of continuous
improvement function to ensure enhanced … in the manufacturing system performance. Results …

System-wide hybrid MPC–PID control of a continuous pharmaceutical tablet manufacturing process via direct compaction

R Singh, M Ierapetritou, R Ramachandran - European Journal of …, 2013 - Elsevier
continuous processes coupled with efficient feedback control … demand for high efficiency,
enhanced product quality, and … It should be noted that in continuous manufacturing, for some …

[HTML][HTML] Continuous manufacturing: a changing processing paradigm

R Hernandez - BioPharm Int, 2015 - processdevelopmentforum.com
continuous manufacturing is well established for bulk chemicals, complex automation and
validation challenges limit continuous applications for biologics manufacturing… offer enhanced

Advanced process monitoring and feedback control to enhance cell culture process production and robustness

A Zhang, VL Tsang, B Moore, V Shen… - Biotechnology and …, 2015 - Wiley Online Library
… introduce enhanced process control strategies to demonstrate fully automated online
monitoring of cell culture metabolites and real-time biomass integrated with a computer-controlled