… , gene and disease context is necessary. Here, we describe current genome editing approaches
for … for each genetic context, in order to achieve enhanced genome editing approaches. …

… gene editing technology influence gene editing efficiencies. These are ordered based on their
approximate impact on genome editing … B Applications for enrichment of gene edited cells …

… Targeted genome editing … to facilitate gene knockout in mouse zygotes without sacrificing
on-target cleavage efficiency. This versatile strategy enables a wide variety of genome editing …

… Furthermore, gene editing has been used to enhance cellular immunotherapy by disrupting
endogenous T cell receptors [78, 79] or the glucocorticoid receptor in T cells in a clinical trial …

… To further assess the utility of the All-in-One Cas9 D10A nickase vector system, we
explored how it could be employed for genome editing in telomerase-immortalized, non-transformed …

… We explored the efficacy of PRDM9-Cas9-catalyzed genome editing across different cell
types, … -Cas9-mediated genome editing and provide an approach to enhance HDR efficiency. …

… are emerging as powerful tools for genome editing. Dual-fluorescent surrogate systems …
scenarios of gene editing experiments. First, we disrupted the endogenous pIAPP gene (3.0 % …

… used for plant genome editing. Clustered regularly interspaced … The majority of plant genome
editing studies have exploited … also considered a promising genome editing tool (Zetsche et …

… repair template to knock in or correct a mutation in the genome. We recently reported the
use of a TALEN genome-editing system to rapidly and efficiently generate mutant alleles of 15 …

… In conclusion, we have shown that CRISPR PLUS greatly enhanced genome editing
efficiency while keeping the off-target effect low relative to C9 control. Three genes in human …