Effect of varying the molecular weight of the MR contrast agent Gd‐DTPApolylysine on blood pharmacokinetics and enhancement patterns

VS Vexler, O Clément… - Journal of Magnetic …, 1994 - Wiley Online Library
… ‐DTPA (diethylenetriaminepentaacetic acid)—polylysine, a … tissue MR imaging signal
enhancement characteristics were studied in … for four Gd‐DTPApolylysine polymers with average …

In vivo and in vitro evaluation of Gd-DTPA-polylysine as a macromolecular contrast agent for magnetic resonance imaging

G SCHUHMANN-GIAMPIERI… - Investigative …, 1991 - journals.lww.com
… The pattern of the size population as well as the average molecular weight of the molecules
was … Spin echo and inversion recovery sequences for gadolinium-DTPA enhanced magnetic …

Polylysine-Gd-DTPAn and Polylysine-Gd-DOTAn Coupled to Anti-CEA F (ab′) 2 Fragments as Potential Immunocontrast Agents: Relaxometry, Biodistribution, and …

C Curtet, F MATON, T HAVET, M SLINKIN… - Investigative …, 1998 - journals.lww.com
… were coupled to polylysine-Gd-DOTA and polylysine-Gd-DTPA. A … an enhancement
corresponds to a 0.01 mM local concentration of Gd. Among the methods for targeting improvement, …

Comparison of gadolinium-DTPA and polylysine-gadolinium-DTPA-enhanced magnetic resonance imaging of hepatocarcinoma in the rat

C Grandin, BE VAN BEERS, R Demeure… - Investigative …, 1995 - journals.lww.com
… T1-weighted images, but the enhancement pattern helps to characterize … enhancement
pattern is better shown on polylysine-Gd-DTPA-enhanced images than on GdDTPA-enhanced

Facilitated magnetic resonance imaging diagnosis of pulmonary disease using a macromolecular blood-pool contrast agent, polylysine-(Gd-DTPA) 40

RC BRASCH, Y BERTHEZENE, VS VEXLER… - Investigative …, 1991 - journals.lww.com
enhancement pattern over 30 minutes, the same pattern … , using polylysine-(Gd-DTPA), the
perfused lung enhanced … the nondependent embolized lung enhanced significantly but only …

Gd‐DTPA‐cascade‐polymer: potential blood pool contrast agent for MR imaging

G Adam, J Neuerburg, E Spüntrup… - Journal of Magnetic …, 1994 - Wiley Online Library
enhancement after injection of either contrast agent. After injection of Gd-DTPA-polymer,
enhancement patterns … with Gd-DTPApolylysine and after 16 seconds with Gd-DTPA-polymer. …

Contrast enhanced high resolution MRI of cutaneous melanomas using Gd‐DTPA and Gd‐DTPApolylysine: experimental results

J Mäurer, FD Knollmann, C Veuskens… - Skin Research and …, 1998 - Wiley Online Library
… evaluation of contrast enhancement patterns in melanoma was developed. … , enhancement
following administration of Gd-DTPA-polylysine did not exceed that caused by Gd-DTPA as a …

High-level conjugation of chelating agents onto immunoglobulins: use of an intermediary poly (L-lysine)-diethylenetriaminepentaacetic acid carrier

Y Manabe, C Longley, P Furmanski - Biochimica et Biophysica Acta (BBA) …, 1986 - Elsevier
… Gd conjugates were enhanced relative to DTPAGd itself. Reuben [18] investigated the
applicability of proton relaxation methods in studying metal ion binding to biological …

Dynamic contrast‐enhanced MR imaging of the upper abdomen: enhancement properties of gadobutrol, gadolinium‐DTPApolylysine, and gadolinium‐DTPA …

G Adam, J Neuerburg, E Spüntrup… - Magnetic resonance …, 1994 - Wiley Online Library
… Peak enhancement of the pancreas after injection of gadolinium-DTPA-polylysine was
seen … This may be helpful for the assessment of the vascularity and permeability patterns of …

Convection enhanced delivery of different molecular weight tracers of gadolinium-tagged polylysine

PA Hardy, D Keeley, G Schorn, E Forman, Y Ai… - Journal of neuroscience …, 2013 - Elsevier
… ), we synthesized Gd-DTPA tagged polylysine tracers of different average MW's approximating
… labeled polylysine compounds, there were consistent enhancement patterns surrounding …