Enteric nervous system development and Hirschsprung's disease: advances in genetic and stem cell studies

TA Heanue, V Pachnis - Nature Reviews Neuroscience, 2007 - nature.com
… Summary of enteric nervous system (ENS) phenotypes observed in various mouse mutant
strains commonly used as Hirschsprung's disease (HSCR) models. Schematic diagrams …

[HTML][HTML] The enteric nervous system

V Sasselli, V Pachnis, AJ Burns - Developmental biology, 2012 - Elsevier
phenotypes, characterised by the absence of enteric … mature neurons, while the full spectrum
of enteric chemical coding … in mature enteric neurons are the NOS neurons around E11.5–…

Neurotransmitters involved in fast excitatory neurotransmission directly activate enteric glial cells

W Boesmans, C Cirillo… - …, 2013 - Wiley Online Library
… are involved in controlling enteric neuron phenotype and ENS … capable of generating enteric
neurons in response to injury. … The MTT is converted by chemical reduction in living cells, to …

[HTML][HTML] Neuro-immune interactions drive tissue programming in intestinal macrophages

I Gabanyi, PA Muller, L Feighery, TY Oliveira… - Cell, 2016 - cell.com
… a pro-inflammatory phenotype when … neurons in the sympathetic ganglia innervating the
intestine. This work identifies a mechanism by which interaction between intestinal neurons and …

Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis

S Kulkarni, MA Micci, J Leser, C Shin… - Proceedings of the …, 2017 - National Acad Sciences
… adult enteric neurons and provide a paradigm for understanding the enteric nervous system
… leads to an intestinal phenotype that resembles human ganglioneuromatosis, a disorder of …

Neuronal differentiation in Schwann cell lineage underlies postnatal neurogenesis in the enteric nervous system

T Uesaka, M Nagashimada… - Journal of Neuroscience, 2015 - Soc Neuroscience
… 6A,B), suggesting that SCPs begin to acquire neuronal phenotype in the perinatal period. …
This study also revises the conventional view that enteric neurons are derived solely from …

Exploring Schwann cell precursor-derived enteric neurogenesis in post-embryonic development and regeneration

WN El-Nachef - 2019 - escholarship.org
… imaging, we sought to explore the origin of enteric neurons that arise in post-embryonic life
… resident neuronal precursors. Figure 4: De novo enteric neurons replace ablated neurons in …

Enteric neural stem cell therapies for enteric neuropathies

CJ McCann, N Thapar - Neurogastroenterology & Motility, 2018 - Wiley Online Library
… of enteric neurons within transplanted intestinal tissues39 … aneural gut segments, chemical
ablation approaches and … NCSC to adopt an enteric neural phenotype in the absence of gut …

Innervation of the pancreas by neurons in the gut

AL Kirchgessner, MD Gershon - Journal of Neuroscience, 1990 - Soc Neuroscience
… indicate that enteric neurons can influence the function of the exocrine and endocrine …
The histochemical demonstration of cytochrome oxidase activity was used for these studies. …

High-and medium-molecular-weight neurofilament proteins define specific neuron types in the guinea-pig enteric nervous system

LR Rivera, M Thacker, JB Furness - Cell and tissue research, 2009 - Springer
… Whole-mount preparations were incubated with antibodies to markers of various classes of
enteric neurons (Table 1), overnight at 4C. The whole-mounts were then washed (3×10 min) …