… prolyl oligopeptidase has also been studied in detail, this review will primarily focus on this
enzyme… the substrate isomerization be negligible with respect to the enzymatic reaction [14]. …

… of serine peptidases, the prolyl oligopeptidase family, cannot … of prolyl oligopeptidase (POP)
has shown that the enzyme is … concentrations, when the enzyme reaction is faster than the …

… the distinctness of the Oligopeptidase group of … enzymes from brain as endo-oligopeptidases
A and B [2,3]. There is little doubt that endo-oligopeptidases A and B were the enzymes that …

… domains are required for enzyme action. This mechanism was verified when the structure
of Sphingomonas capsulata POP in the open configuration was resolved (Shan et al., 2005). …

… , the first-order enzyme reaction must be much slower (/'lie > … by prolyl oligopeptidase, only
the low-pH form of the enzyme … acylation, dominates the reaction in the physiological pH range…

… the non-enzymatic reaction rate. The remaining activity may derive from the free energy
of binding, desolvation and the oxyanion binding site (electrophilic catalysis) (reviewed by [21]). …

… No structure from the prolyl oligopeptidase family is available to date. Recently, we … prolyl
oligopeptidase isolated from porcine muscle. This paper describes the structure of the enzyme …

… activity in one of them. In conclusion, we have identified a new type within POP enzymes that
exhibits not only unique activity but also a … in terms of both enzyme activity and mechanism. …

… enzyme, prolyl oligopeptidase is implicated in a variety of disorders of the central nervous
system. For example, a decrease in serum prolyl oligopeptidase activity has … of the enzyme. In …

Prolyl oligopeptidase (POP) is a serine endopeptidase that hydrolyses proline-containing
peptides shorter than 30 amino acids. POP may be associated with cognitive functions, …