… growth factors (TGF-ca). The clinical correlations with its expression were studied in 77
nonsmall cell lung cancers (NSCLC). They were stained for epidermal growth factor receptor (…

… EGFR Expression in Lung Tumors. The epidermal growth factor receptor is commonly
overexpressed in non-small cell lung cancer (NSCLC; reviewed in Ref. 5) and head and neck …

… Growth-inhibitory effectsof epidermal growth factor and over expressionof its receptorson
human squamouscell carcinomas in culture. Cancer Rca.,46: 1648-1653, 1986. …

… It is well known that epidermal growth factor receptor (EGFR) … in some patients with small
cell lung cancers (SCLC). In this … The vast majority of epidermal growth factor receptor (EGFR) …

… , and apoptosis, are in clinical development to treat lung cancer. Among these targeted
therapies are the oral, small-molecule epidermal growth factor receptor-tyrosine kinase (EGFR-TK…

… that target the epidermal growth factor receptor (EGFR) provide important insights for new
lung cancer therapies, as well as for the broader field of targeted cancer therapies. We review …

… downstream targets is thought to yield more aggressive tumor phenotypes. Mutations in
epidermal growth factor receptor have been discovered in association with some lung cancers. …

… Epidermal growth factor (EGF) promotes the growth ofcultured benign and malignant … :
EGF, epidermal growth factor; EGF-R 1, a murine monoclonal epidermal growth factor receptor-…

… in the epidermal growth factor receptor gene (EGFR) confer hypersensitivity to the tyrosine
kinase inhibitors gefitinib and erlotinib in patients with advanced non–small-cell lung cancer. …

… Several endogenous ligands for EGFRs are known, but the most important stimulatory
ligands are epidermal growth factor (EGF) and transforming growth factor α (TGFα). After ligand …