Genes, epigenetic regulation and environmental factors: which is the most relevant in developing autoimmune diseases?

KH Costenbader, S Gay, ME Alarcón-Riquelme… - Autoimmunity …, 2012 - Elsevier
… field in autoimmune diseases. We review the roles of genetic factors, epigenetic regulation
and the … –Barr virus, and reproductive hormones in the pathogenesis of autoimmune disease. …

[HTML][HTML] An update on epigenetic regulation in autoimmune diseases

X Mei, B Zhang, M Zhao, Q Lu - Journal of translational autoimmunity, 2022 - Elsevier
Epigenetics is considered a reversible and inheritable … Aberrant epigenetics is essential in
the onset of autoimmune disease (AIDs… Almost all the autoimmune susceptible genes, such as …

Epigenetic regulation of B cells and its role in autoimmune pathogenesis

F Xiao, K Rui, X Shi, H Wu, X Cai, KO Lui… - Cellular & Molecular …, 2022 - nature.com
… In this review, we present an up-to-date overview of epigenetic mechanisms … epigenetic
dysregulation in B cells and highlight its contribution to the development of autoimmune diseases

The pathogenic role of dysregulated epigenetic modifications in autoimmune diseases

H Wu, Y Chen, H Zhu, M Zhao, Q Lu - Frontiers in immunology, 2019 - frontiersin.org
… via epigenetic alterations. Similar phenomena have been found in other autoimmune diseases:
dysregulation of epigenetic … The specific epigenetic regulations in autoimmune diseases

Epigenetic perspectives on systemic autoimmune disease

P Karagianni, AG Tzioufas - Journal of Autoimmunity, 2019 - Elsevier
… the development of most autoimmune diseases. Besides changes in epigenetic modifications,
… studying the contribution of epigenetic regulation to the pathogenesis of autoimmune

[HTML][HTML] Environmental triggers and epigenetic deregulation in autoimmune disease

BM Javierre, H Hernando, E Ballestar - Discovery medicine, 2011 - discoverymedicine.com
epigenetic profiles has not yet been filled. Here we review a number of studies describing
epigenetic alterations in autoimmune diseases … The breakdown of epigenetic regulation is now …

Epigenetic control of autoimmune diseases: from bench to bedside

A Picascia, V Grimaldi, O Pignalosa, MR De Pascale… - Clinical …, 2015 - Elsevier
… Moreover, we could use epigenetic-related biomarkers to … of the epigenetic involvement in
the field of autoimmune diseases … the understanding of epigenetic regulation will significantly …

Epigenetic alterations underlying autoimmune diseases

S Aslani, M Mahmoudi, J Karami, AR Jamshidi… - …, 2016 - Taylor & Francis
… Several cell processes from differentiation to development and function are believed to
be signed by epigenetic regulation, including tumor cells [Citation173] and immune cells in …

Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases

CM Hedrich, GC Tsokos - Trends in molecular medicine, 2011 - cell.com
… pathophysiological relevance of epigenetic patterns in these autoimmune diseases is limited,
… of the main epigenetic mechanisms in the pathogenesis of autoimmune diseases while …

Epigenetic alterations in cellular immunity: new insights into autoimmune diseases

Z Wang, Q Lu, Z Wang - Cellular Physiology and Biochemistry, 2017 - karger.com
… Due to the epigenetic bridge which links the gene and environment factors to … more epigenetic
regulations in autoimmune diseases. Immune events occur in the presence of epigenetic