Epigenetic toxicology as toxicant-induced changes in intracellular signalling leading to altered gap junctional intercellular communication
JE Trosko, CC Chang, B Upham, M Wilson - Toxicology Letters, 1998 - Elsevier
… be non-genotoxic, ie epigenetic, mechanisms that could directly … of epigenetic toxicology or
assays to measure epigenetic events … On the other hand, an epigenetic event can be either a …
assays to measure epigenetic events … On the other hand, an epigenetic event can be either a …
The dynamic epigenome and its implications in toxicology
M Szyf - Toxicological Sciences, 2007 - academic.oup.com
… epigenetic mechanisms impact on the toxic action of xenobiotics is very limited, it is anticipated
that in the future, epigenetics … different epigenetic marks and that DNA methylation signals …
that in the future, epigenetics … different epigenetic marks and that DNA methylation signals …
… intercellular communication as a biological “Rosetta stone” in understanding, in a systems biological manner, stem cell behavior, mechanisms of epigenetic toxicology …
JE Trosko - Journal of Membrane Biology, 2007 - Springer
In spite of the early speculation by Loewenstein that one of the critical distinguishing
phenotypes of cancers from normal cells was the dysfunction of gap junctional intercellular …
phenotypes of cancers from normal cells was the dysfunction of gap junctional intercellular …
Epigenetic targets of some toxicologically relevant metals: a review of the literature
TF Cheng, S Choudhuri… - … of Applied Toxicology, 2012 - Wiley Online Library
… Like many cellular signaling pathways, there … epigenetic changes and concurrent alterations
of gene expression that underscore how studies on the environmentally-induced epigenetic …
of gene expression that underscore how studies on the environmentally-induced epigenetic …
Ochratoxin A: potential epigenetic mechanisms of toxicity and carcinogenicity
B Schilter, M Marin-Kuan, T Delatour… - Food additives and …, 2005 - Taylor & Francis
… toxicity previously reported will be briefly discussed and their relevance as potential epigenetic
… cascades involving phosphorylation-activation reactions aimed at transducing signals …
… cascades involving phosphorylation-activation reactions aimed at transducing signals …
Ochratoxin A carcinogenicity involves a complex network of epigenetic mechanisms
M Marin-Kuan, C Cavin, T Delatour, B Schilter - Toxicon, 2008 - Elsevier
… increasingly documented epigenetic cellular effects of OTA and their potential toxicological
relevance … stress and the activation of specific cell signalling pathways, is responsible for OTA …
relevance … stress and the activation of specific cell signalling pathways, is responsible for OTA …
[图书][B] Toxicology and epigenetics
SC Sahu - 2012 - books.google.com
… modulators of epigenetic targets. However, very little informationonthe potential toxicological
consequenceof … Better understanding ofthe epigenetic mechanism ofhuman diseases, …
consequenceof … Better understanding ofthe epigenetic mechanism ofhuman diseases, …
[HTML][HTML] Integration of epigenetic mechanisms into non-genotoxic carcinogenicity hazard assessment: Focus on DNA methylation and histone modifications
D Desaulniers, P Vasseur, A Jacobs… - International Journal of …, 2021 - mdpi.com
… Deregulated expression of any of 25 epigenetic toxicity pathway components (SET1,
MLL1, … of the receptor tyrosine kinase-extracellular signal-regulated kinase signaling (RTK-ERK) …
MLL1, … of the receptor tyrosine kinase-extracellular signal-regulated kinase signaling (RTK-ERK) …
[HTML][HTML] A Tox21 approach to altered epigenetic landscapes: assessing epigenetic toxicity pathways leading to altered gene expression and oncogenic transformation …
CL Parfett, D Desaulniers - International journal of molecular sciences, 2017 - mdpi.com
… shows that disruption of epigenetic processes by chemicals … and readers) that convey the
epigenetic information. Evidence is … induce toxicity through disturbance of functional epigenetic …
epigenetic information. Evidence is … induce toxicity through disturbance of functional epigenetic …
Environmental toxicants—Induced epigenetic alterations and their reversers
M Kim, M Bae, H Na, M Yang - Journal of Environmental Science …, 2012 - Taylor & Francis
… multiple exposures to them can alleviate or mask epigenetic toxicity in real life. Our present
review … of Wnt and calcium signaling, vascular development, and epigenetic mechanisms as …
review … of Wnt and calcium signaling, vascular development, and epigenetic mechanisms as …
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