Epigenetic toxicology as toxicant-induced changes in intracellular signalling leading to altered gap junctional intercellular communication

JE Trosko, CC Chang, B Upham, M Wilson - Toxicology Letters, 1998 - Elsevier
… be non-genotoxic, ie epigenetic, mechanisms that could directly … of epigenetic toxicology or
assays to measure epigenetic events … On the other hand, an epigenetic event can be either a …

The dynamic epigenome and its implications in toxicology

M Szyf - Toxicological Sciences, 2007 - academic.oup.com
epigenetic mechanisms impact on the toxic action of xenobiotics is very limited, it is anticipated
that in the future, epigenetics … different epigenetic marks and that DNA methylation signals

… intercellular communication as a biological “Rosetta stone” in understanding, in a systems biological manner, stem cell behavior, mechanisms of epigenetic toxicology …

JE Trosko - Journal of Membrane Biology, 2007 - Springer
In spite of the early speculation by Loewenstein that one of the critical distinguishing
phenotypes of cancers from normal cells was the dysfunction of gap junctional intercellular

Epigenetic targets of some toxicologically relevant metals: a review of the literature

TF Cheng, S Choudhuri… - … of Applied Toxicology, 2012 - Wiley Online Library
… Like many cellular signaling pathways, there … epigenetic changes and concurrent alterations
of gene expression that underscore how studies on the environmentally-induced epigenetic

Ochratoxin A: potential epigenetic mechanisms of toxicity and carcinogenicity

B Schilter, M Marin-Kuan, T Delatour… - Food additives and …, 2005 - Taylor & Francis
toxicity previously reported will be briefly discussed and their relevance as potential epigenetic
… cascades involving phosphorylation-activation reactions aimed at transducing signals

Ochratoxin A carcinogenicity involves a complex network of epigenetic mechanisms

M Marin-Kuan, C Cavin, T Delatour, B Schilter - Toxicon, 2008 - Elsevier
… increasingly documented epigenetic cellular effects of OTA and their potential toxicological
relevance … stress and the activation of specific cell signalling pathways, is responsible for OTA …

[图书][B] Toxicology and epigenetics

SC Sahu - 2012 - books.google.com
… modulators of epigenetic targets. However, very little informationonthe potential toxicological
consequenceof … Better understanding ofthe epigenetic mechanism ofhuman diseases, …

[HTML][HTML] Integration of epigenetic mechanisms into non-genotoxic carcinogenicity hazard assessment: Focus on DNA methylation and histone modifications

D Desaulniers, P Vasseur, A Jacobs… - International Journal of …, 2021 - mdpi.com
… Deregulated expression of any of 25 epigenetic toxicity pathway components (SET1,
MLL1, … of the receptor tyrosine kinase-extracellular signal-regulated kinase signaling (RTK-ERK) …

[HTML][HTML] A Tox21 approach to altered epigenetic landscapes: assessing epigenetic toxicity pathways leading to altered gene expression and oncogenic transformation …

CL Parfett, D Desaulniers - International journal of molecular sciences, 2017 - mdpi.com
… shows that disruption of epigenetic processes by chemicals … and readers) that convey the
epigenetic information. Evidence is … induce toxicity through disturbance of functional epigenetic

Environmental toxicants—Induced epigenetic alterations and their reversers

M Kim, M Bae, H Na, M Yang - Journal of Environmental Science …, 2012 - Taylor & Francis
… multiple exposures to them can alleviate or mask epigenetic toxicity in real life. Our present
review … of Wnt and calcium signaling, vascular development, and epigenetic mechanisms as …