… To clarify this point, we investigated the effects of TGF-β1 on Cx43 expression and subsequent
gap … kinase (ERK)-mitogen-activated protein kinases (MAPKs) in TGF-β1-Cx43 signaling …

… However, its effect on Cx43 gap junction in endothelial cells remains unexplored. Here we …
Cx43 gap junction in endothelial cells and the implication of MAPKs signaling in this process. …

… MAPK cascade is activated, thereby enhancing Cx43 expression. Our finding that inhibition
of any of the three MAPKs … by PD98059 indicating an involvement of the p38 MAPK and ERK. …

… Gap junctions are specialized … on gap junction activity occur via the organization of the
gap junction structures themselves. This is a direct result of the short half-life of the primary gap …

… , Connexin43 (Cx43), is phosphorylated at several sites in its C-terminus. The tumor-promoting
phorbol ester TPA strongly inhibits Cx43 gap … of Cx43 and inhibition of gap junction …

… inhibits GJIC and rapidly induces Cx43 GJ internalization via CME. Our … of Cx43 at serines
255, 262, 279/282, and 368 by MAPK and PKC that correlates with GJIC inhibition and Cx43-…

… Cx43 and MAPK pathway. Consistent with the oncogenic role of Cx43 in bladder cancer,
overexpression of Cx43 … of JNK and ERK signaling in stable Cx43-overexpression bladder …

… ; also known as mitogen-activated protein kinases, MAPKs) are … ERKs and demonstrate
that activated ERKs are essential for the inhibition of GJIC, Cx43 hyperphosphorylation, and gap …

… In our study, inhibition of MAPK-ERK1/2 and p38 … Cx43 is a known substrate of ERK1/2, thus
inhibition of ERK … studies indicate that MAPK-dependent phosphorylation of Cx43 on serine …

… In view of two confirmed pathways (MAPK and PI3K pathways) involved in Aldo-induced MC
… PI3K inhibitor LY294002 prevented the activation of ERK and phosphorylation of Cx43 [14]. …