Scribble regulates an EMT polarity pathway through modulation of MAPK-ERK signaling to mediate junction formation

IA Elsum, C Martin, PO Humbert - Journal of cell science, 2013 - journals.biologists.com
… , lack tight junctions under standard tissue culture conditions (… the formation of functional
tight junctions. We provide evidence for a pathway in which Scribble regulates MAPK-ERK

The involvement of the ERK-MAPK pathway in TGF-β1–mediated connexin43-gap junction formation in chondrocytes

Q Wang, C Zhou, D Zhang, J Zou, W Liu… - Connective Tissue …, 2019 - Taylor & Francis
… Furthermore, the inhibitor of ERK attenuated the increases of Cx43 expressions and
functional gap junction formations induced by TGF-β1, while cross-talk between ERK-MAPK and …

Essential role of the ERK/MAPK pathway in blood-placental barrier formation

V Nadeau, J Charron - Development, 2014 - journals.biologists.com
formation. Map2k1 +/− Map2k2 +/− mutants show reduced vascularization of the labyrinth and
defective formation … To define the cell type-specific contribution of the ERK/MAPK pathway …

Activation of ERK1/2 MAP kinase pathway induces tight junction disruption in human corneal epithelial cells

Y Wang, J Zhang, X Yi, XY Fu-Shin - Experimental eye research, 2004 - Elsevier
… the MAPK signaling pathway plays a key role in the formation and … ERK MAP kinase
signaling and increase TJ permeability, PKC may play a role in the activation of ERK MAP kinase

Restoration of E-cadherin cell-cell junctions requires both expression of E-cadherin and suppression of ERK MAP kinase activation in Ras-transformed breast …

Q Li, RR Mattingly - Neoplasia, 2008 - Elsevier
… prevent the formation of functional E-cadherin junctions by preventing the appropriate subcellular
localization of E-cadherin. We have found that inhibition of ERK MAPK activation is …

Inhibition of ERKMAP kinase signaling by RSK during Drosophila development

M Kim, JH Lee, H Koh, SY Lee, C Jang… - The EMBO …, 2006 - embopress.org
… to an enhanced ERK‐dependent cellular differentiation such as ectopic photoreceptor‐ and
vein‐cell formation. Conversely, overexpression of RSK dramatically suppressed the ERK‐…

The MAPK/ERK-signaling pathway regulates the expression and distribution of tight junction proteins in the mouse proximal epididymis

B Kim, S Breton - Biology of reproduction, 2016 - academic.oup.com
… We examine here the role of the MAPK/ERK1/2 pathway in the regulation of TJ proteins in
… the MAPK/ERK1/2 pathway in the regulation of cell-cell events that control the formation and …

Cytokines induce tight junction disassembly in airway cells via an EGFR-dependent MAPK/ERK1/2-pathway

L Petecchia, F Sabatini, C Usai, E Caci… - Laboratory …, 2012 - nature.com
formation of TJs during epithelial cellular polarization. At the initial stage of cell–cell contact
of epithelial cells, primordial spot-like junctions are formed … line that MAPK/ERK pathway has …

ERK-MAPK signaling opposes Rho-kinase to promote endothelial cell survival and sprouting during angiogenesis

G Mavria, Y Vercoulen, M Yeo, H Paterson… - Cancer cell, 2006 - cell.com
… Temporal and spatial modulation of Rho GTPases during in vitro formation of capillary
vascular network. Adherens junctions and myosin light chain as targets of Rac1 and RhoA. …

Claudin-7 inhibits human lung cancer cell migration and invasion through ERK/MAPK signaling pathway

Z Lu, L Ding, H Hong, J Hoggard, Q Lu… - Experimental cell research, 2011 - Elsevier
… inhibitor of ERK/MAPK pathway, was able to block the motile effect. Claudin-7 formed stable
complexes with claudin-1 and -3 and was able to recruit them to the cell-cell junction area in …