… of Erlotinib derivatives containing 1,2,3-triazole ring were designed and synthesized. Cell-based
assay discovered … mutation, is still most sensitive to Erlotinib. However, several of the …

… In conclusion, a series of novel erlotinib derivatives bearing different sugar moieties were
synthesized and their putative antitumor activities assessed via inhibition of cancer cell …

… Among the derivatives made, compounds 10a, 10c, and 21g showed superb potency, … In
this study we present a series of esterase hydrolyzable NSAIDs conjugated with erlotinib, which …

… of this novel template led to the discovery of highly selective compounds that target EGFR. …
a pharmacophore for the mode of action of erlotinib, which prevents activation of EGFR kinase …

… dominant structures and discovered a series of inhibitors … , we found that the BFE of erlotinib
was lower than that of … R127 (Figure 8B), but erlotinib could not interact with this region due …

… -substituted-4-anilinoquinazolines and Erlotinib was performed in EGFR-dependent A549
… We report here two new series of EGFR inhibitors containing a 6-amino-substituted group or …

… first discovered that the 4-anilinoquinazoline derivative PD153035 possesses specific …
quinazoline derivatives have been synthesized, including reversible inhibitors, such as erlotinib, …

… In summary, a series of erlotinib derivatives containing 1,2,3-triazole rings were prepared …
Some of the compounds exhibited better antiproliferation activities than the parent erlotinib. …

… the early stage of drug discovery can reduce the possibility of … triazole compounds based on
the erlotinib core structure in a … In this study, a series of erlotinib derivatives containing 1,2,3-…

… followed to prepare new series of fused quinoline derivatives. Molecular hybridization involves
… to that of erlotinib over EGFR L858R and 17 times higher than that of erlotinib over EGFR …