… efficacy of combined erlotinib–pemetrexed in patients with … The combination of erlotinib
and pemetrexed could potentially … In a preclinical study of erlotinib and pemetrexed in human …

… to select the optimal combination schedule of erlotinib and pemetrexed for the treatment of …
determinants of erlotinib sensitivity, were exposed to pemetrexed and erlotinib using different …

7526 Background: PEM and ERL have been approved as second-line monotherapy for
locally advanced or metastatic NSCLC. The combination of PEM + ERL showed synergistic …

… Combined treatment with erlotinib and pemetrexed could potentially augment the antitumor
… safety profile of combined administration of the two agents in pretreated NSCLC patients. …

… not support the combination use of intermittent erlotinib and pemetrexed in patients with EGFR
… Therefore, from our study, combination administration of pemetrexed and erlotinib is not …

… [17] conducted a study comparing erlotinib plus pemetrexed versus each single agent in …
patients with advanced nonsquamous NSCLC. In this study, pemetrexed-erlotinib combination …

… Forty-two patients with lung cancer that responded to TKIs for as least 6 months before …
received sequential pemetrexed or pemetrexed plus platinum followed by gefitinib or erlotinib. …

… if exposure to erlotinib before pemetrexed is avoided [15]. Therefore, we conducted a phase
II study of the combination of pemetrexed and erlotinib in pretreated NSCLC patients without …

… In conclusion, this study demonstrated improved PFS by combining pemetrexed and
erlotinib in never-smokers with advanced NSCLC. The benefit was seen across multiple clinical …

… Thus, the results of this study suggest that the pemetrexed + erlotinib combination might
have clinical advantage over single-agent pemetrexed as second-line treatment of non-…