Safety and efficacy of erlotinib in first-relapse glioblastoma: a phase II open-label study

WKA Yung, JJ Vredenburgh, TF Cloughesy… - Neuro …, 2010 - academic.oup.com
… of 41 patients with advanced gliomas responded to erlotinib, … of tissue from glioblastoma
patients treated with erlotinib or gefitinib … of single-agent erlotinib in patients with first-relapse …

[HTML][HTML] Erlotinib is effective in pancreatic cancer with epidermal growth factor receptor mutations: a randomized, open-label, prospective trial

JP Wang, CY Wu, YC Yeh, YM Shyr, YY Wu, CY Kuo… - Oncotarget, 2015 - ncbi.nlm.nih.gov
… Furthermore, KRAS mutation status did not predict how patients would respond to erlotinib
in our study, which is in line with the pivotal PA.3 study [17]. The small numbers of patients in …

… first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 …

R Rosell, E Carcereny, R Gervais… - The lancet …, 2012 - thelancet.com
… (11 [13%] of 84 patients given erlotinib vs none of 82 patients in the chemotherapy group), …
patients on erlotinib had treatment-related severe adverse events compared with 16 patients

[HTML][HTML] A prospective, phase II, open-label study (JO22903) of first-line erlotinib in Japanese patients with epidermal growth factor receptor (EGFR) mutation-positive …

K Goto, M Nishio, N Yamamoto, K Chikamori, T Hida… - Lung Cancer, 2013 - Elsevier
patients in this study received treatment with erlotinib for a longer duration than patients
Six out of the total 108 patients included in the erlotinib second-/third-line Japanese studies …

Final survival and safety results from a multicenter, openlabel, phase 3b trial of erlotinib in patients with advanced nonsmall cell lung cancer

DR Spigel, M Lin, V O'Neill… - … International Journal of …, 2008 - Wiley Online Library
… 3b, multicenter, open-label trial of erlotinib in patients with … and safety of erlotinib monotherapy
in patients with advanced … of erlotinib-treated patients in subpopulations defined by other …

An open-label study to describe pharmacokinetic parameters of erlotinib in patients with advanced solid tumors with adequate and moderately impaired hepatic …

CL O'Bryant, P Haluska, L Rosen… - Cancer chemotherapy …, 2012 - Springer
… Registration trials for erlotinib were restricted to patients with … 150 mg dose of erlotinib in
cancer patients with moderate hepatic … erlotinib protein binding in cancer patients with MHI. …

[HTML][HTML] … gemcitabine/cisplatin in patients with advanced EGFR mutation-positive non-small-cell lung cancer: analyses from the phase III, randomized, open-label …

YL Wu, C Zhou, CK Liam, G Wu, X Liu, Z Zhong, S Lu… - Annals of oncology, 2015 - Elsevier
Patients were stratified by EGFR mutation type, ECOG PS, gender, and country. … , erlotinib
patients could crossover to receive GP and GP patients could crossover to receive erlotinib. All …

… bevacizumab versus erlotinib alone in patients with EGFR-positive advanced non-squamous non-small-cell lung cancer (NEJ026): interim analysis of an open-label …

H Saito, T Fukuhara, N Furuya, K Watanabe… - The Lancet …, 2019 - thelancet.com
… of erlotinib plus bevacizumab with erlotinib alone in patientspatients given bevacizumab
and erlotinib had improved progression-free survival compared with patients given erlotinib

… as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised …

C Zhou, YL Wu, G Chen, J Feng, XQ Liu… - The lancet …, 2011 - thelancet.com
… 83 patients were randomly assigned to receive erlotinib and 82 to receive gemcitabine plus
carboplatin; 82 in the erlotinib … of erlotinib was 50 mg/day; any patient receiving an erlotinib

… and design of a randomized open-label phase III trial comparing bevacizumab plus erlotinib versus erlotinib alone as first-line treatment of patients with EGFR-mutated …

C Gridelli, A Rossi, F Ciardiello, F De Marinis… - Clinical Lung Cancer, 2016 - Elsevier
Patients and Methods … plus erlotinib study (BEVERLY) is a randomized, open-label,
phase III trial investigating first-line erlotinib plus bevacizumab versus erlotinib in patients with …