Comparison of gefitinib versus erlotinib in patients with nonsmall cell lung cancer who failed previous chemotherapy

ST Kim, J Lee, J Kim, YW Won, JM Sun, J Yun… - Cancer, 2010 - Wiley Online Library
… that gefitinib and erlotinib appeared to have similar outcomes in patients with advanced/…
chemotherapy. The overall response rates and disease control rates in the gefitinib- and erlotinib

Randomized phase II study of gefitinib versus erlotinib in patients with advanced non-small cell lung cancer who failed previous chemotherapy

ST Kim, JE Uhm, J Lee, J Sun, I Sohn, SW Kim… - Lung Cancer, 2012 - Elsevier
… to be the sequela of previous platinum-based chemotherapy. … II trial of erlotinib or standard
chemotherapy in patients with … for patients who developed moderate to severe skin rash on …

[HTML][HTML] A randomized phase II study comparing erlotinib versus erlotinib with alternating chemotherapy in relapsed non-small-cell lung cancer patients: the NVALT-10 …

JG Aerts, H Codrington, NAG Lankheet, S Burgers… - Annals of oncology, 2013 - Elsevier
… Therefore, we designed a study in patients who failed previous cytotoxic treatment to
compare PFS between erlotinib and intercalating erlotinib with pemetrexed for NSQ cell lung …

High efficacy of erlotinib in Taiwanese NSCLC patients in an expanded access program study previously treated with chemotherapy

RP Perng, CH Yang, YM Chen, GC Chang, MC Lin… - Lung Cancer, 2008 - Elsevier
… (EGFR) pathway with tyrosine kinase inhibitor (TKI) is an effective and promising salvage
treatment for NSCLC patients who have failed previous chemotherapy, especially for Asian …

Approval summary for erlotinib for treatment of patients with locally advanced or metastatic non–small cell lung cancer after failure of at least one prior chemotherapy …

JR Johnson, M Cohen, R Sridhara, YF Chen… - Clinical Cancer …, 2005 - AACR
… EGFR status measured by immunohistochemistry was not a predictor of tumor response in
previous lung cancer clinical trials with erlotinib or gefitinib, a related EGFR tyrosine kinase …

First-line erlotinib in patients with advanced non-small-cell lung cancer unsuitable for chemotherapy (TOPICAL): a double-blind, placebo-controlled, phase 3 trial

SM Lee, I Khan, S Upadhyay, C Lewanski… - The lancet …, 2012 - thelancet.com
… assigned 350 patients to receive erlotinib and 320 to receive placebo. We followed up patients
until … Exclusion criteria were previous treatment with any biological anticancer therapy; …

Randomized, placebo-controlled, phase II study of sequential erlotinib and chemotherapy as first-line treatment for advanced non–small-cell lung cancer

TSK Mok, YL Wu, CJ Yu, C Zhou, YM Chen… - Journal of Clinical …, 2009 - ascopubs.org
… combination of chemotherapy with erlotinib, followed by erlotinib maintenance therapy. …
administration of erlotinib with chemotherapy has demonstrated promising results in patients with …

Chemotherapy with erlotinib or chemotherapy alone in advanced non‐small cell lung cancer with acquired resistance to EGFR tyrosine kinase inhibitors

SB Goldberg, GR Oxnard, S Digumarthy… - The …, 2013 - academic.oup.com
chemotherapy alone after the development of TKI resistance. We found that continuing
erlotinib with chemotherapy … a reasonable treatment option for patients with EGFR‐mutant lung …

Chemotherapy plus erlotinib versus chemotherapy alone for treating advanced non-small cell lung cancer: a meta-analysis

JL Xu, B Jin, ZH Ren, YQ Lou, ZR Zhou, QZ Yang… - PloS one, 2015 - journals.plos.org
… In this meta-analysis, continuous erlotinib plus chemotherapy versus chemotherapy alone
failed to show improvements in PFS and OS. A previous systematic review demonstrated that …

Efficacy and safety of erlotinib versus chemotherapy in second-line treatment of patients with advanced, non-small-cell lung cancer with poor prognosis (TITAN): a …

T Ciuleanu, L Stelmakh, S Cicenas, S Miliauskas… - The lancet …, 2012 - thelancet.com
… The main exclusion criteria were previous exposure to anti-human-EGFR-directed drugs
or … and dihydrofolate reductase inhibitors); previous chemotherapy or systemic anti-neoplastic …