SEARCH: a phase III, randomized, double-blind, placebo-controlled trial of sorafenib plus erlotinib in patients with advanced hepatocellular carcinoma
AX Zhu, O Rosmorduc, TRJ Evans, PJ Ross… - Journal of Clinical …, 2015 - ascopubs.org
… with sorafenib were 86 days in the sorafenib/erlotinib arm and 123 days in the sorafenib/…
erlotinib for patients in the sorafenib/erlotinib group were 86 and 157 days, respectively. …
erlotinib for patients in the sorafenib/erlotinib group were 86 and 157 days, respectively. …
Phase I targeted combination trial of sorafenib and erlotinib in patients with advanced solid tumors
… These trials of sorafenib plus gefitinib and erlotinib plus bevacizumab seem to echo our
findings in their nonoverlapping toxicity profiles, suggesting that simultaneous inhibition of the …
findings in their nonoverlapping toxicity profiles, suggesting that simultaneous inhibition of the …
Randomized, double-blind, placebo-controlled, phase II trial of sorafenib and erlotinib or erlotinib alone in previously treated advanced non–small-cell lung cancer
DR Spigel, HA Burris III, FA Greco… - Journal of clinical …, 2011 - ascopubs.org
… sorafenib/erlotinib versus 1.77 months for placebo/erlotinib (… for sorafenib/erlotinib versus
4.5 months for placebo/erlotinib … for sorafenib/erlotinib was suggested among 43 patients with …
4.5 months for placebo/erlotinib … for sorafenib/erlotinib was suggested among 43 patients with …
[HTML][HTML] SEARCH: a phase III, randomized, double-blind, placebo-controlled trial of sorafenib plus erlotinib in patients with hepatocellular carcinoma (HCC)
AX Zhu, O Rosmorduc, J Evans, P Ross, A Santoro… - Annals of …, 2012 - Elsevier
… sorafenib in the sorafenib plus erlotinib and sorafenib plus placebo arms were 768 and 773
mg, respectively, while the median daily doses of erlotinib … in the sorafenib plus erlotinib arm, …
mg, respectively, while the median daily doses of erlotinib … in the sorafenib plus erlotinib arm, …
Biomarker analyses of clinical outcomes in patients with advanced hepatocellular carcinoma treated with sorafenib with or without erlotinib in the SEARCH trial
… ) in the sorafenib plus erlotinib group compared with sorafenib plus placebo, … sorafenib
plus erlotinib group (13). Despite this trial not demonstrating a benefit for the addition of erlotinib …
plus erlotinib group (13). Despite this trial not demonstrating a benefit for the addition of erlotinib …
Phase II trial of sorafenib and erlotinib in advanced pancreatic cancer
DB Cardin, L Goff, CI Li, Y Shyr, C Winkler… - Cancer …, 2014 - Wiley Online Library
… with sorafenib in the treatment of patients with advanced pancreatic … cancer patients treated
with erlotinib, was performed. Patients received sorafenib 400 mg daily along with erlotinib …
with erlotinib, was performed. Patients received sorafenib 400 mg daily along with erlotinib …
Phase I/II study of sorafenib in combination with erlotinib for recurrent glioblastoma as part of a 3-arm sequential accrual clinical trial: NABTC 05-02
H Chen, J Kuhn, KR Lamborn, LE Abrey… - Neuro-Oncology …, 2020 - academic.oup.com
… This study identified the MTD and DLTs for sorafenib and erlotinib … —sorafenib and erlotinib—of
this trial and discuss the sequential accrual design in detail. Sorafenib and erlotinib were …
this trial and discuss the sequential accrual design in detail. Sorafenib and erlotinib were …
Sorafenib and continued erlotinib or sorafenib alone in patients with advanced non-small cell lung cancer progressing on erlotinib: A randomized phase II study of the …
DR Spigel, MS Rubin, VG Gian, DL Shipley… - Lung Cancer, 2017 - Elsevier
… phase II study, we compared treatment with single agent sorafenib to the combination of
sorafenib/erlotinib, in patients who relapsed after benefitting from single agent erlotinib. …
sorafenib/erlotinib, in patients who relapsed after benefitting from single agent erlotinib. …
A multicenter phase II study of sorafenib in combination with erlotinib in patients with advanced non-small cell lung cancer (KCSG-0806)
SM Lim, BC Cho, SW Kim, SY Kang, DS Heo, HT Kim… - Lung cancer, 2016 - Elsevier
… designed a clinical trial of combining erlotinib and sorafenib in advanced NSCLC patients. In
… combination of sorafenib and erlotinib in previously treated patients with advanced NSCLC. …
… combination of sorafenib and erlotinib in previously treated patients with advanced NSCLC. …
A multicenter phase II study of erlotinib and sorafenib in chemotherapy-naive patients with advanced non–small cell lung cancer
JSW Lind, AMC Dingemans, HJM Groen… - Clinical Cancer …, 2010 - AACR
… of sorafenib monotherapy in NSCLC (6–8). In addition, a phase I study established the safety
and tolerability of combining sorafenib and erlotinib … of sorafenib combined with erlotinib in …
and tolerability of combining sorafenib and erlotinib … of sorafenib combined with erlotinib in …
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