Randomized phase II study of fulvestrant and erlotinib compared with erlotinib alone in patients with advanced or metastatic non-small cell lung cancer

EB Garon, JM Siegfried, LP Stabile, PA Young… - Lung Cancer, 2018 - Elsevier
… explored, but no current phase III data show superiority of an … An association between
estrogens and lung cancer risk first … when an increase in lung cancer mortality was observed in …

Design of phase II cancer trials using a continuous endpoint of change in tumor size: application to a study of sorafenib and erlotinib in non–small-cell lung cancer

TG Karrison, ML Maitland, WM Stadler… - … of the National Cancer …, 2007 - academic.oup.com
… -molecule tyrosine kinase inhibitor erlotinib may be considered … consisting of the oral agents
erlotinib and sorafenib, an … activity than erlotinib alone to merit a subsequent phase III trial. …

Gefitinib and erlotinib in metastatic non-small cell lung cancer: a meta-analysis of toxicity and efficacy of randomized clinical trials

M Burotto, EE Manasanch, J Wilkerson, T Fojo - The oncologist, 2015 - academic.oup.com
… or gefitinib as treatment of advanced or metastatic stage IIIB … Cancer classification. The
following study selection criteria were used: phase II and phase III randomized studies of erlotinib

[HTML][HTML] Maintenance erlotinib versus erlotinib at disease progression in patients with advanced non-small-cell lung cancer who have not progressed following …

S Cicènas, SL Geater, P Petrov, Y Hotko, G Hooper… - Lung Cancer, 2016 - Elsevier
… IUNO was a randomized, double-blind, multicenter, placebo-controlled phase III trial of
maintenance erlotinib versus erlotinib at the time of disease progression in patients with …

Experience with erlotinib in the treatment of non-small cell lung cancer

L Landi, F Cappuzzo - Therapeutic Advances in Respiratory …, 2015 - journals.sagepub.com
… The ATLAS trial was a phase III study comparing maintenance erlotinib plus bevacizumab
versus bevacizumab alone in patients with NSCLC without progressive disease after four …

… Phase III Study of First-Line Erlotinib Followed by Second-Line Cisplatin/Gemcitabine Versus First-Line Cisplatin/Gemcitabine Followed by Second-Line Erlotinib in …

C Gridelli, C Butts, F Ciardiello, R Feld, C Gallo… - Clinical lung cancer, 2008 - Elsevier
Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced non-small
cell lung cancer: the Tarceva Lung Cancer … TRIBUTE: a phase III trial of erlotinib

[HTML][HTML] … the randomized, placebo-controlled, phase 3, FASTACT-2 study of intercalated erlotinib with first-line chemotherapy in advanced non-small-cell lung cancer  …

TSK Mok, JS Lee, L Zhang, C Yu, S Thongprasert… - Annals of …, 2012 - Elsevier
… FASTACT-2 is a randomized, placebo-controlled, phase 3 study in first-line advanced
NSCLC, which met its primary endpoint of significantly prolonged PFS with intercalated erlotinib

[HTML][HTML] Survival benefit with erlotinib maintenance therapy in patients with advanced non-small-cell lung cancer (NSCLC) according to response to first-line …

B Coudert, T Ciuleanu, K Park, YL Wu, G Giaccone… - Annals of oncology, 2012 - Elsevier
… In the placebo-controlled phase III SATURN study, maintenance erlotinib after first-line
chemotherapy demonstrated significantly prolonged progression-free survival (PFS) and overall …

Erlotinib in cancer treatment

MA Bareschino, C Schettino, T Troiani, E Martinelli… - Annals of oncology, 2007 - Elsevier
… in three common lung cancer symptoms, showed that patients receiving … Phase III
randomized trials with erlotinib in advanced non-small cell lung cancer and pancreatic cancer

Results of a phase III trial of erlotinib (OSI-774) combined with cisplatin and gemcitabine (GC) chemotherapy in advanced non-small cell lung cancer (NSCLC)

U Gatzemeier, A Pluzanska, A Szczesna… - Journal of Clinical …, 2004 - ascopubs.org
… -naive patients with unresectable stage III or IV NSCLC; age … erlotinib combined with GC
was not significantly inferior to GC alone, with the exception of increased incidences of grade 3