Phase I/II trial of cetuximab and erlotinib in patients with lung adenocarcinoma and acquired resistance to erlotinib

YY Janjigian, CG Azzoli, LM Krug, LK Pereira… - Clinical cancer …, 2011 - AACR
… Patients with grade 2 or more skin toxicity on erlotinib monotherapy were not eligible. The
… growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib …

Clinical pharmacokinetics of erlotinib in patients with solid tumors and exposure‐safety relationship in patients with non–small cell lung cancer

JF Lu, SM Eppler, J Wolf, M Hamilton… - Clinical …, 2006 - Wiley Online Library
… and erlotinib exposure in non-small cell lung cancer patients treated with single-agent
erlotinib. … By use of erlotinib monotherapy as a reference, CL/F was 10.5% and 18.1% faster in …

[HTML][HTML] Erlotinib in advanced non-small cell lung cancer: efficacy and safety findings of the global phase IV Tarceva Lung Cancer Survival Treatment study

M Reck, N van Zandwijk, C Gridelli, Z Baliko… - Journal of Thoracic …, 2010 - Elsevier
… IV study of erlotinib, designed to allow access to erlotinib monotherapy for patients with …
for other erlotinib trials. In each country, recruitment continued until erlotinib was granted a …

A phase II study of erlotinib as first-line treatment of advanced non-small cell lung cancer

G Giaccone, T Lechevalier, N Thatcher… - Journal of Clinical …, 2005 - ascopubs.org
… Conclusions: Erlotinib is active and well tolerated as first-line monotherapy in advanced
NSCLC. Responses were seen in … Further assessment of erlotinib in this setting is warranted. …

Enhanced sensitivity to the HER1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib hydrochloride in chemotherapy-resistant tumor cell lines

Q Dai, YH Ling, M Lia, YY Zou, G Kroog, KK Iwata… - Clinical Cancer …, 2005 - AACR
… In phase II clinical studies, oral erlotinib monotherapy has shown antitumor activity in
patients with advanced non–small cell lung cancer, head and neck cancer, and ovarian cancer

Erlotinib in patients with advanced lung squamous cell carcinoma

CL Chiang, CM Tsai, TY Chou, YM Chen… - Cancer chemotherapy …, 2013 - Springer
… The aim of this study was to review the treatment response of erlotinib monotherapy in …
with erlotinib monotherapy during January 2006 to October 2011. We included lung cancer

Role of erlotinib in the treatment of non-small cell lung cancer: clinical outcomes in wild-type epidermal growth factor receptor patients

B Piperdi, R Perez-Soler - Drugs, 2012 - Springer
… was 34% with erlotinib monotherapy compared with 47% with erlotinib and chemotherapy.
The … predictors of erlotinib efficacy in advanced non-small cell lung cancer? Clin Cancer Res …

Erlotinib in combination with bevacizumab has potential benefit in non-small cell lung cancer: a systematic review and meta-analysis of randomized clinical trials

B Zhao, W Zhang, D Yu, J Xu, Y Wei - Lung Cancer, 2018 - Elsevier
… Third, although 10 recent well-designed RCTs were included, until this meta-analysis no
data focusing on the merits of erlotinib plus bevacizumab over monotherapy in EGFR- or KRAS-…

Experience with erlotinib in the treatment of non-small cell lung cancer

L Landi, F Cappuzzo - Therapeutic Advances in Respiratory …, 2015 - journals.sagepub.com
… (EGFR TKIs), such as erlotinib and gefitinib, have demonstrated … more effective than standard
monotherapy with cytotoxics in the … data on erlotinib in the treatment of advanced NSCLC. …

Chemotherapy with erlotinib or chemotherapy alone in advanced non‐small cell lung cancer with acquired resistance to EGFR tyrosine kinase inhibitors

SB Goldberg, GR Oxnard, S Digumarthy… - The …, 2013 - academic.oup.com
Purpose. Epidermal growth factor receptor (EGFR)‐mutant non‐small cell lung cancer has
an oncogene‐addicted biology that confers sensitivity to EGFR tyrosine kinase inhibitors (TKIs…