A randomized phase II trial of erlotinib vs. S-1 as a third- or fourth-line therapy for patients with wild-type EGFR non-small cell lung cancer (HOT1002)

…, Hokkaido Lung Cancer Clinical Study Group - Cancer chemotherapy …, 2017 - Springer
… equivalent efficacy in patients who received erlotinib as third-line compared with those who
received erlotinib as second-line [13, 14]. Thus, erlotinib is a candidate of the standard third- …

A prospective, multicenter phase II trial of low-dose erlotinib monotherapy for patients with previously treated non-small cell lung cancer (NSCLC) with activating …

Y Nakahara, Y Hosomi, K Yamada, H Okamoto, T Kato… - 2014 - ascopubs.org
… Background: Erlotinib and gefitinib … erlotinib is approximately 3.5 times higher than that of
gefitinib when administered at the respective approved dose, treatment with low-dose erlotinib

A phase II trial of erlotinib in patients with EGFR wild-type advanced non-small-cell lung cancer

T Kobayashi, T Koizumi, T Agatsuma, M Yasuo… - Cancer chemotherapy …, 2012 - Springer
… Therefore, we performed this prospective study to investigate the efficacy and tolerability
of erlotinib monotherapy in Japanese patients with wild-type EGFR as a potential therapeutic …

Clinical and economic review of erlotinib in non-small-cell lung cancer

K Yeung, JJ Carlson - Expert review of pharmacoeconomics & …, 2012 - Taylor & Francis
… of erlotinib for advanced non-small-cell lung cancer. Overall, the studies found that erlotinib,
… studies evaluating erlotinib as monotherapy have expanded the role of erlotinib to the first-…

Addition of bevacizumab enhances antitumor activity of erlotinib against non-small cell lung cancer xenografts depending on VEGF expression

H Li, K Takayama, S Wang, Y Shiraishi… - Cancer chemotherapy …, 2014 - Springer
erlotinib is difficult to detect in erlotinib-sensitive tumor, we investigated the efficacy of erlotinib
plus bevacizumab in erlotinib-… Erlotinib monotherapy is approved for treatment of patients …

Clinical efficacy of erlotinib in patients previously treated for advanced non‐small cell lung cancer

S Zhou, S Ren, L Yan, L Zhang, L Tang, J Zhang… - …, 2009 - Wiley Online Library
… In our study, monotherapy with erlotinib achieved an overall response of 35.7% and a DCR
of 76.8% in 112 Chinese patients, which is significantly higher than the 12 to 19% response …

Impact of bevacizumab in combination with erlotinib on EGFR‐mutated non–small cell lung cancer xenograft models with T790M mutation or MET amplification

K Furugaki, J Fukumura, T Iwai… - … Journal of Cancer, 2016 - Wiley Online Library
… , which is an HGF expression positive gastric cell line. Effect of monotherapy with BEV or …
+ERL, we examined the effect of each as a monotherapy. In the HCC827 xenograft model, ERL …

Afatinib monotherapy in patients with metastatic squamous cell carcinoma of the lung progressing after erlotinib/gefitinib (E/G) and chemotherapy: Interim subset …

JH Kim, F Grossi, F De Marinis, M Cobo, JCH Yang… - 2012 - ascopubs.org
… of Part A was performed to assess afatinib monotherapy. Results: Patient enrolment into Part
A was … Conclusions: Afatinib monotherapy demonstrated encouraging activity in treatment-…

Tyrosine kinase inhibitor combination therapy in first-line treatment of non-small-cell lung cancer: systematic review and network meta-analysis

S Batson, SA Mitchell, R Windisch… - OncoTargets and …, 2017 - Taylor & Francis
… The SR identified two such studies, one comparing erlotinib plus bevacizumab versus
erlotinib monotherapy Citation19 and a second comparing gefitinib plus concurrent or sequential …

… of tivantinib (ARQ 197) plus erlotinib versus erlotinib alone in previously treated patients with locally advanced or metastatic nonsquamous non–small-cell lung cancer

G Scagliotti, J Von Pawel, S Novello… - Journal of Clinical …, 2015 - ascopubs.org
Lung cancer is a leading cause of cancer-related death, with … -cell lung cancer (NSCLC)
represents 85% of all lung cancers. For … Phase I and II studies of tivantinib as monotherapy or in …