Acquired resistance of lung adenocarcinoma to EGFR-tyrosine kinase inhibitors gefitinib and erlotinib
Y Xu, H Liu, J Chen, Q Zhou - Cancer biology & therapy, 2010 - Taylor & Francis
… cancers acquire resistance to gefitinib or erlotinib have not … in EGFR can lead to gefitinib or
erlotinib resistance. In 2005, … mutation linked to acquired resistance to gefitinib: a change from …
erlotinib resistance. In 2005, … mutation linked to acquired resistance to gefitinib: a change from …
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
… of five patients with acquired resistance to gefitinib or erlotinib, … tumor progressed on adjuvant
gefitinib after complete resection … Moreover, no tumors with acquired resistance had KRAS …
gefitinib after complete resection … Moreover, no tumors with acquired resistance had KRAS …
Prospective assessment of discontinuation and reinitiation of erlotinib or gefitinib in patients with acquired resistance to erlotinib or gefitinib followed by the addition of …
… after restarting erlotinib or gefitinib, … erlotinib or gefitinib. We recommend a randomized trial
to assess the value of continuing erlotinib or gefitinib after development of acquired resistance…
to assess the value of continuing erlotinib or gefitinib after development of acquired resistance…
Chemotherapy with erlotinib or chemotherapy alone in advanced non‐small cell lung cancer with acquired resistance to EGFR tyrosine kinase inhibitors
SB Goldberg, GR Oxnard, S Digumarthy… - The …, 2013 - academic.oup.com
… Medical records of patients with stage IV NSCLC [13] harboring an EGFR mutation were
reviewed to identify all those who had ever received an EGFR TKI (erlotinib, gefitinib, or …
reviewed to identify all those who had ever received an EGFR TKI (erlotinib, gefitinib, or …
Molecular analysis of NSCLC patients with acquired resistance to gefitinib or erlotinib
W Pao, MN Balak, GJ Riely, AR Li… - Journal of Clinical …, 2006 - ascopubs.org
… acquired resistance to TKI monotherapy. More patients are being studied, and we are trying
to elucidate determinants of acquired resistance … of acquired resistance to gefitinib or erlotinib…
to elucidate determinants of acquired resistance … of acquired resistance to gefitinib or erlotinib…
[HTML][HTML] … II trial of dasatinib for patients with acquired resistance to treatment with the epidermal growth factor receptor tyrosine kinase inhibitors erlotinib or gefitinib
… erlotinib or gefitinib in … erlotinib in patients with acquired resistance while also adding
second-line treatment agents and amended this protocol to allow patients to continue erlotinib in …
second-line treatment agents and amended this protocol to allow patients to continue erlotinib in …
Phase I/II trial of cetuximab and erlotinib in patients with lung adenocarcinoma and acquired resistance to erlotinib
YY Janjigian, CG Azzoli, LM Krug, LK Pereira… - Clinical cancer …, 2011 - AACR
… These results show that, although combined EGFR inhibition is a viable strategy for
patients with acquired resistance to erlotinib and gefitinib (with tolerable safety profile), the …
patients with acquired resistance to erlotinib and gefitinib (with tolerable safety profile), the …
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
… To determine whether lung cancers that acquire resistance to either gefitinib or erlotinib
display additional and/or specific genetic alterations that might play a role in disease progression…
display additional and/or specific genetic alterations that might play a role in disease progression…
Phase II study of erlotinib for acquired resistance to gefitinib in patients with advanced non-small cell lung cancer
A Horiike, N Yamamoto, H Tanaka… - Anticancer …, 2014 - ar.iiarjournals.org
… a phase II study to evaluate the efficacy of erlotinib against acquired resistance to gefitinib. …
, erlotinib has been shown to achieve disease control after acquired resistance to gefitinib. …
, erlotinib has been shown to achieve disease control after acquired resistance to gefitinib. …
[HTML][HTML] Prospective assessment of continuation of erlotinib or gefitinib in patients with acquired resistance to erlotinib or gefitinib followed by the addition of …
N Yoshimura, K Okishio, S Mitsuoka, T Kimura… - Journal of Thoracic …, 2013 - Elsevier
… cause of acquired resistance to gefitinib and erlotinib is … resistance to these drugs. , 8
Investigators performed reconstitution experiments in vitro to estimate whether acquired resistance …
Investigators performed reconstitution experiments in vitro to estimate whether acquired resistance …
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