… cancers acquire resistance to gefitinib or erlotinib have not … in EGFR can lead to gefitinib or
erlotinib resistance. In 2005, … mutation linked to acquired resistance to gefitinib: a change from …

… of five patients with acquired resistance to gefitinib or erlotinib, … tumor progressed on adjuvant
gefitinib after complete resection … Moreover, no tumors with acquired resistance had KRAS …

… after restarting erlotinib or gefitinib, … erlotinib or gefitinib. We recommend a randomized trial
to assess the value of continuing erlotinib or gefitinib after development of acquired resistance…

… Medical records of patients with stage IV NSCLC [13] harboring an EGFR mutation were
reviewed to identify all those who had ever received an EGFR TKI (erlotinib, gefitinib, or …

… acquired resistance to TKI monotherapy. More patients are being studied, and we are trying
to elucidate determinants of acquired resistance … of acquired resistance to gefitinib or erlotinib…

… erlotinib or gefitinib in … erlotinib in patients with acquired resistance while also adding
second-line treatment agents and amended this protocol to allow patients to continue erlotinib in …

… These results show that, although combined EGFR inhibition is a viable strategy for
patients with acquired resistance to erlotinib and gefitinib (with tolerable safety profile), the …

… To determine whether lung cancers that acquire resistance to either gefitinib or erlotinib
display additional and/or specific genetic alterations that might play a role in disease progression…

… a phase II study to evaluate the efficacy of erlotinib against acquired resistance to gefitinib. …
, erlotinib has been shown to achieve disease control after acquired resistance to gefitinib. …

… cause of acquired resistance to gefitinib and erlotinib is … resistance to these drugs. , 8
Investigators performed reconstitution experiments in vitro to estimate whether acquired resistance …