Clinical pharmacokinetics of erlotinib in patients with solid tumors and exposure‐safety relationship in patients with non–small cell lung cancer
JF Lu, SM Eppler, J Wolf, M Hamilton… - Clinical …, 2006 - Wiley Online Library
… The primary objective of this study was to characterize the pharmacokinetics of erlotinib in a
… on its pharmacokinetics. The second objective was to evaluate the relationship of erlotinib …
… on its pharmacokinetics. The second objective was to evaluate the relationship of erlotinib …
Pharmacokinetic-pharmacodynamic modeling of the anticancer effect of erlotinib in a human non-small cell lung cancer xenograft mouse model
… Erlotinib is used to treat non-small-cell lung cancer (NSCLC), … the relationship between
erlotinib plasma concentrations and … and tumor growth inhibition in a human non-small-cell lung …
erlotinib plasma concentrations and … and tumor growth inhibition in a human non-small-cell lung …
Population pharmacokinetics of Erlotinib in patients with non–small cell Lung Cancer: its application for individualized dosing regimens in older patients
E Cardoso, M Guidi, N Khoudour… - Clinical …, 2020 - Elsevier
… Erlotinib is an oral first-generation epidermal growth factor receptor (EGFR) tyrosine kinase
inhibitor approved for non–small cell lung cancers (… the pharmacokinetic profile of erlotinib in …
inhibitor approved for non–small cell lung cancers (… the pharmacokinetic profile of erlotinib in …
Correlation between erlotinib pharmacokinetics, cutaneous toxicity and clinical outcomes in patients with advanced non-small cell lung cancer (NSCLC)
M Tiseo, R Andreoli, F Gelsomino, P Mozzoni, C Azzoni… - Lung cancer, 2014 - Elsevier
… with erlotinib. Several explanations have been suggested, including pharmacokinetic and
… The purposes of this study were to characterize erlotinib pharmacokinetic and to correlate …
… The purposes of this study were to characterize erlotinib pharmacokinetic and to correlate …
Population pharmacokinetics/pharmacodynamics of erlotinib and pharmacogenomic analysis of plasma and cerebrospinal fluid drug concentrations in Japanese …
M Fukudo, Y Ikemi, Y Togashi, K Masago… - … pharmacokinetics, 2013 - Springer
… variations on the clinical outcomes of erlotinib remains fully investigated. The …
pharmacokinetics/pharmacodynamics of erlotinib in Japanese patients with non-small cell lung …
pharmacokinetics/pharmacodynamics of erlotinib in Japanese patients with non-small cell lung …
Schedule-dependent cytotoxic synergism of pemetrexed and erlotinib in human non–small cell lung cancer cells
T Li, YH Ling, ID Goldman, R Perez-Soler - Clinical cancer research, 2007 - AACR
… schedule of erlotinib and pemetrexed for the treatment of relapsed non–small cell lung cancer
(… Experimental Design: Human NSCLC cell lines, with variable expression of the known …
(… Experimental Design: Human NSCLC cell lines, with variable expression of the known …
Pharmacokinetics and pharmacodynamics: maximizing the clinical potential of Erlotinib (Tarceva)
M Hidalgo, D Bloedow - Seminars in oncology, 2003 - Elsevier
… In agreement with data from a phase II trial with erlotinib in patients with non-small cell
lung cancer, 17 findings from recent phase II studies with two anti-HER1/EGFR monoclonal …
lung cancer, 17 findings from recent phase II studies with two anti-HER1/EGFR monoclonal …
Pharmacokinetics of gefitinib and erlotinib
D Levêque - The Lancet Oncology, 2011 - thelancet.com
… inhibitors erlotinib and gefitinib in EGFR mutation-positive non-small-cell lung cancer could
be … Erlotinib has a seventimes greater AUC than does gefitinib, which might explain its better …
be … Erlotinib has a seventimes greater AUC than does gefitinib, which might explain its better …
[HTML][HTML] Effects of pharmacokinetic processes and varied dosing schedules on the dynamics of acquired resistance to erlotinib in EGFR-mutant lung cancer
… This approach showed that the metabolic clearance of erlotinib occurs … the pharmacokinetic
rate of erlotinib elimination from the body. We considered a function governing the erlotinib …
rate of erlotinib elimination from the body. We considered a function governing the erlotinib …
Phase I/II study of the Src inhibitor dasatinib in combination with erlotinib in advanced non–small-cell lung cancer
EB Haura, T Tanvetyanon, A Chiappori… - Journal of Clinical …, 2010 - ascopubs.org
… pharmacokinetics of erlotinib were affected by the coadministration of dasatinib, we compared
the pharmacokinetic parameters of erlotinib … because similar pharmacokinetic parameter …
the pharmacokinetic parameters of erlotinib … because similar pharmacokinetic parameter …
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