… The IC 50 values of erlotinib in these resistant cell lines are 3- to 20-fold lower than their …
Erlotinib resistance indices remained close to 1 in other resistant sublines A2780/CDDP, KB/…

… We developed resistant cells (HCC4006ER) from erlotinib-sensitive HCC4006 cells …
concentrations of erlotinib. Acquired resistance mechanisms of HCC4006ER cells were analyzed. …

… and erlotinib; however, drug-resistant tumors eventually emerge. In 60% of cases, resistant
… Here, we describe the establishment of erlotinib resistance in lung tumors, which were …

… erlotinib resistance. … erlotinib resistance in HNC and suggest that therapeutic inhibition of
Axl by small molecule drugs or specific miRNAs might overcome anti-EGFR therapy resistance…

… growth factor receptor (VEGFR) inhibitor, BMS-690514, that exerts antiproliferative and
proapoptotic effects on NSCLC cell lines, in particular on cells that are resistant to erlotinib due to …

… Other oncogenes, such as the insulin-like growth factor-I receptor, may also play a role in
resistance to EGFR TKIs in non-EGFR mutated cells (48). Despite a rapidly growing …

… -like growth factor-1 receptor (IGF-IR) pathway is also implicated in the resistance of gefitinib
and … in the IGF-IR–mediated acquired resistance to erlotinib in NSCLC cells have not been …

… It will be important to continue to study preclinical models and tumors from NSCLC patients
that have developed gefitinib/erlotinib resistance to uncover novel resistance mechanisms. …

… Erlotinib-resistant PC-9ER cells were generated from PC-9 NSCLC cells, which harbor an …
growth factor beta (TGF-β) pathway in cell motility, and tested the effects of erlotinib and TGF-β …

… were significantly more effective than erlotinib or gefitinib alone. Erlotinib resistance was …
Conclusion: These studies suggest that erlotinib resistance may be associated with a rise in …