[HTML][HTML] Mitochondrial dysfunction as a driver of cognitive impairment in Alzheimer's disease

C Sharma, S Kim, Y Nam, UJ Jung, SR Kim - International Journal of …, 2021 - mdpi.com
… the molecular mechanisms for mitochondrial dysfunction contributing to cognitive impairment
in AD. … This intracellular movement is essential for maintaining normal neuronal polarity, …

Mechanisms of mitochondrial diseases

E Ylikallio, A Suomalainen - Annals of medicine, 2012 - Taylor & Francis
Mitochondria are essential organelles with multiple functions, the most well known …
mitochondrial dysfunction can result from a multitude of mechanisms other than direct impairment

Mitochondrial dysfunction in metabolism and ageing: shared mechanisms and outcomes?

G López-Lluch, JD Hernández-Camacho… - Biogerontology, 2018 - Springer
Mitochondria are key in the metabolism of aerobic organisms and in ageing … Mitochondria
are essential for obtaining ATP from glucose and fatty acids but also in many other essential

Signaling pathways in mitochondrial dysfunction and aging

C Mammucari, R Rizzuto - Mechanisms of ageing and development, 2010 - Elsevier
… Control of life and death by mitochondrial calcium pathways Mitochondria are essential
mediators of … Impairment of mitochondrial function caused by ROS-induced mtDNA damage, lipid …

Mitochondrial Autophagy–An Essential Quality Control Mechanism for Myocardial Homeostasis–

RL Thomas, ÅB Gustafsson - Circulation Journal, 2013 - jstage.jst.go.jp
… breakdown is impaired, causing it to accumulate on the outer mitochondrial membrane
and … , Parkin phosphorylation, or phosphorylation of mitochondrial targets.A recent study by …

[HTML][HTML] Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: Recent advances

W Wang, F Zhao, X Ma, G Perry, X Zhu - Molecular neurodegeneration, 2020 - Springer
essential role of mitochondria dysfunction in the pathogenesis of AD and discuss mechanisms
underlying mitochondrial … the essential role and mechanisms underlying impaired energy …

[HTML][HTML] Targeting mitochondrial impairment in Parkinson's disease: challenges and opportunities

J Prasuhn, RL Davis, KR Kumar - Frontiers in cell and developmental …, 2021 - frontiersin.org
… into the diversity of mechanisms governing mitochondrial dysfunction in PD. Thus, targeting
… It is essential to recognise that these pathways often influence one another and that each of …

Mitochondrial dysfunction in aging

Y Guo, T Guan, K Shafiq, Q Yu, X Jiao, D Na… - Ageing Research …, 2023 - Elsevier
… damaged mitochondria to ensure that mitochondria are … mitochondrial dysfunction-induced
senescence. This review summarizes mechanisms essential for maintaining mitochondrial

Mitochondrial dysfunction in schizophrenia: pathways, mechanisms and implications

A Rajasekaran, G Venkatasubramanian, M Berk… - Neuroscience & …, 2015 - Elsevier
Mitochondria are also essential to many aspects of neurodevelopment and neuronal functions.
However, mitochondrial impairment … one of the widely appreciated mechanisms that has …

Mitochondrial and metabolic dysfunction in ageing and age-related diseases

JA Amorim, G Coppotelli, AP Rolo… - Nature Reviews …, 2022 - nature.com
Mitochondria are essential for life, as they have a pivotal role … Mitochondrial dysfunction can
lead to severe impairment of … the underlying mechanism driving mitochondrial dysfunction in …