Glycine has important neurotransmitter functions at inhibitory and excitatory synapses in the …
The effective synaptic concentrations of glycine are regulated by glycine transporters (GlyTs)…

… glycine as a co-agonist. We have analysed the physiological roles and regulation of GlyT1
and GlyT2 by generating transporter… In conclusion, glycine has both co-agonist and regulatory …

… Glycine transporter inhibitors may find application in the … , regulation and pharmacology
of the glycine transporters (… This condition is essential to ensure the filling-up of synaptic …

… Glycine transporters are endogenous regulators of the dual functions of … The non-essential
amino acid glycine is a signalling molecule that has two physiological functions in the central …

… In this review we focus on the crosstalk between Glu and glycine (Gly), whose … Gly transporters
that remove or release it into the medium in a regulated manner. The GlyT1 transporter is …

… --dependent glycine transporters GlyT1 … glycine encephalopathy (OMIM 605899). These
findings highlight the importance of these transporters in regulating the levels of synaptic glycine…

… Glycine transporters play important roles in the regulation of brain levels of glycine, an amino
… Whole‐brain glycine levels are tightly regulated by glycine transporters, which transport …

… Two second messenger pathways are illustrated, which are correlated with the regulation
of glycine transporter activity, such as nNOS/sGC/PKG-1, PKCα and PI3K/Akt/GSK-3β. PKCα= …

… The glycine transporter subtype 1 (GlyT1) is widely … system and has been implicated in
the regulation of N-methyl-D-… life, GlyT1 is essential for regulating glycine concentrations at …

… strychnine insensitive glycine modulatory site (GMS). Pharmacological studies suggest that
the glycine transporter, GlyT1, maintains subsaturating concentrations of glycine at synaptic …