Advancing the development of new tuberculosis treatment regimens: the essential role of translational and clinical pharmacology and microbiology
KE Dooley, D Hanna, V Mave, K Eisenach… - PLoS …, 2019 - journals.plos.org
… regimens move into late-phase trials with important uncertainties (about the real likelihood
that a regimen will produce cure … the standard-of-care regimen) that traditional microbiologic …
that a regimen will produce cure … the standard-of-care regimen) that traditional microbiologic …
Principles for constructing a tuberculosis treatment regimen: the role and definition of core and companion drugs
A Van Deun, T Decroo, A Piubello… - … of Tuberculosis and …, 2018 - ingentaconnect.com
… Although it cannot be considered a key companion drug for every patient with DR-TB, it may
still have an important role to play in patients with remaining activity on strains with the inhA …
still have an important role to play in patients with remaining activity on strains with the inhA …
Advances in the development of new tuberculosis drugs and treatment regimens
… repurposed for TB treatment showed that it could have a major part to play in the treatment
of MDR-TB 37 . An observational study evaluated the effectiveness of standardized regimens …
of MDR-TB 37 . An observational study evaluated the effectiveness of standardized regimens …
Tuberculosis: pathogenesis, current treatment regimens and new drug targets
SSR Alsayed, H Gunosewoyo - International journal of molecular …, 2023 - mdpi.com
… and sequestration thereof, were found to play a critical role in the disease progression [10]. …
), which are the major lipid components of the M. tb robust cell wall that are essential for the …
), which are the major lipid components of the M. tb robust cell wall that are essential for the …
Treatment of tuberculosis: update 2010
WW Yew, C Lange, CC Leung - 2011 - Eur Respiratory Soc
… treatment of tuberculosis. Where appropriate, evidence levels for the recommended treatment
regimens … integral part thereof, which includes enablers, incentives, education and holistic …
regimens … integral part thereof, which includes enablers, incentives, education and holistic …
Tuberculosis treatment: dangerous regimens?[Counterpoint]
HL Rieder, T Arnadottir, A Trébucq… - … of Tuberculosis and …, 2001 - ingentaconnect.com
… in mind the basic principles of tuberculosis treatment when … treatment regimens and means
for the delivery of treatment will ultimately prove fatal for an increasing number of tuberculosis …
for the delivery of treatment will ultimately prove fatal for an increasing number of tuberculosis …
Fixed-dose combination drugs for tuberculosis: application in standardised treatment regimens
B Blomberg, B Fourie - Drugs, 2003 - Springer
… for a number of alternative treatment regimens with regards to … plays and important role in
rapidly reducing the number of TB … Isoniazid and rifampicin have a pivotal role in anti-TB short-…
rapidly reducing the number of TB … Isoniazid and rifampicin have a pivotal role in anti-TB short-…
International standards for tuberculosis care
PC Hopewell, M Pai, D Maher, M Uplekar… - The Lancet infectious …, 2006 - thelancet.com
… treating a patient for tuberculosis is assuming an important public-health responsibility. To
fulfil this responsibility the practitioner must not only prescribe an appropriate regimen, but …
fulfil this responsibility the practitioner must not only prescribe an appropriate regimen, but …
Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies
… Gatifloxacin, a component of the Bangladesh regimen, is no longer on the WHO essential
drug list due to concerns over dysglycaemia, and it has been replaced in the shorter drug …
drug list due to concerns over dysglycaemia, and it has been replaced in the shorter drug …
Role of individual drugs in the chemotherapy of tuberculosis
DA Mitchison - The international journal of tuberculosis and …, 2000 - ingentaconnect.com
… ) to a basic regimen of … role of each of the major drugs, isoniazid, rifampicin and pyrazinamide,
mainly in their capacity to reduce the viable bacterial population. Evidence on their roles …
mainly in their capacity to reduce the viable bacterial population. Evidence on their roles …
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