… ; therefore, its role and relationship with other pathways warrant further investigation… estrogen
and progesterone and how their signaling pathways play a critical role in colorectal cancer …

… However, few data are currently available on the polyamine pathway and estrogenic
modulation in colorectal cancer. In human colorectal tissue we have shown significantly higher ER …

… This review examines the preclinical and clinical evidence of the estrogenic pathway in the
development of adenomatous polyps and CRC, and the potential to modulate this process as …

… is promoted and regulated by ER pathway, it can in return … estrogen (estrone) to the more
potent estrogen (estradiol) [38]. Moreover, the results in this study suggested that PR pathway …

… Despite recent advances in screening and treatment, colorectal cancer (CRC) remains the
second most common cause of cancer-related death in both sexes worldwide. CRC may grow …

… Abnormal estrogen receptor signaling may increase the risk of development of a variety of
diseases including colorectal cancer (CRC). Estrogen receptor beta (ERβ) is the predominant …

… colorectal cancer … estrogens and to interconvert E 1 and E 2 . In addition, our results suggest
for the first time that “in vitro” human colorectal cancer cells are able to metabolize estrogens …

… we analyze the estrogen pathway as a possible therapeutic avenue in colorectal cancer, we
… molecular mechanisms of estrogen-mediated protection against colorectal tumorigenesis, …

… Colorectal cancer risk and rs3760806 in SULT2B1 were … in colorectal tumor tissues than
in normal tissues in the Cancer … estrogen metabolic pathway genes confer colorectal cancer …

… Epidemiological data have shown that the risk of colorectal cancer is reduced among
postmenopausal hormone users, compared with those who have never used these hormones. …