Estrogen receptor β potentiates the antiproliferative effect of raloxifene and affects the cell migration and invasion in HCT-116 colon cancer cells

Z Tu, Y Ma, J Tian, H Li, W Akers, S Achilefu… - Journal of cancer …, 2012 - Springer
Estrogen receptor β (ERβ) is the predominant ER in the colorectal epithelium, whose
expression is greatly … (ER) isoform involved in E2 protection against colorectal cancer. Since …

Preliminary study on the expression of Estrogen Receptor Beta (ERβ) in colorectal carcinoma

MX Keh, A Azmahani, H Faroque… - Asian Journal of …, 2020 - journal.unisza.edu.my
… development of colorectal cancer treatments. It is therefore believed that estrogen-mediated …
Hence, the purpose of this study was to determine the expression of estrogen receptor beta (…

Gene signatures of estrogen and progesterone receptor pathways predict the prognosis of colorectal cancer

D Liu - The FEBS journal, 2016 - Wiley Online Library
… The associations of estrogen receptor (ER) and progesterone receptor (PR) pathways with
the prognosis of colorectal cancer (CRC) are still controversial. The aim of this study was to …

Oestrogen and colorectal cancer: mechanisms and controversies

PA Foster - International journal of colorectal disease, 2013 - Springer
… The role of oestrogen metabolism and action in colorectal cancer (CRC) is controversial. An
… Evidence also suggests that protective effects are modulated through oestrogen receptor

Estrogen metabolism in human colorectal cancer cells

G Fiorelli, L Picariello, V Martineti, I Tognarini… - The Journal of Steroid …, 2002 - Elsevier
… In the present study, the CRC estrogen receptor β (ERβ) positive HCT8, HCT116, DLD-1
and LoVo cell lines were evaluated for expression of functional 17β-hydroxysteroid …

17β-estradiol in colorectal cancer: friend or foe?

Z Wu, C Xiao, J Wang, M Zhou, F You, X Li - Cell Communication and …, 2024 - Springer
… As the most potent estrogen, E2 mediates its effects by binding to nuclear estrogen
receptors (ERα, ERβ) and the membrane-associated G protein-coupled estrogen receptor (GPER). …

[PDF][PDF] A novel shift in estrogen receptor expression occurs as estradiol suppresses inflammation-associated colon tumor formation

CM Armstrong, AR Billimek, KF Allred… - … Relat Cancer, 2013 - researchgate.net
… Jiang H, Teng R, Wang Q, Zhang X, Wang H, Wang Z, Cao J & Teng L 2008 Transcriptional
analysis of estrogen receptor a variant mRNAs in colorectal cancers and their matched …

The biological role of estrogen receptors α and β in cancer

ST Pearce, VC Jordan - Critical reviews in oncology/hematology, 2004 - Elsevier
… of estrogen are mediated by estrogen receptors α and β. The ERs are steroid hormone receptors
… prevention of breast, prostate and colon cancer is a result of a higher incidence of these …

Estrogen receptor α variant ERα46 mediates growth inhibition and apoptosis of human HT-29 colon adenocarcinoma cells in the presence of 17β-oestradiol

H Jiang, R Teng, Q Wang, X Zhang, H Wang… - Chinese medical …, 2008 - mednexus.org
… In this study,we compared the expression of ERa46 mRNA in 32 normaI colorectal tissues
and their matched colorectal cancer … suggest that estrogen plays a role in colorectal cancer

Estrogen receptor beta influences the inflammatory p65 cistrome in colon cancer cells

R Indukuri, L Hases, A Archer, C Williams - Frontiers in endocrinology, 2021 - frontiersin.org
… Inflammation is a primary component of both initiation and promotion of colorectal cancer
(CRC). Cytokines secreted by macrophages, including tumor necrosis factor alpha (TNFα), …