… We have targeted both the estrogen receptor (ER) and the epidermal growth factor receptor
(EGFR) pathways using an ER antagonist, fulvestrant (“Faslodex”), and the selective EGFR …

… as single agents or in combination with other growth factor receptor-targeting drugs such as
… agencies in combination with exemestane in postmenopausal advanced hormone receptor-…

… combination resulted in a reduction in metabolic energetics of the cells (Figure 6B). RNA-Seq
analysis also showed that when we combined 4-OHT and SEL the expression of targets of …

… ligands may be of therapeutic value, particularly in combination with drugs targeting the
Erb-B2 receptor network. A combination of this type is undoubtedly required for better inhibition …

Over the past two decades, we have learned that estrogens play important physiological …
biological effects of estrogen are mediated by not one but two distinct estrogen receptors (ERs), …

… The anti-tumor effect of selective estrogen receptor modulators (SERMs) and XCT790 (XCT)
used alone or in combination were evaluated in both of ERα-positive (ERα+) and ERα-…

… anti-HER2-targeted agent. Both studies showed that the combined approach is
associated with … We analyze clinical evidence regarding the combined use of AIs and anti-HER2-targeted …

… The actions of estrogens are mediated by estrogen receptors, ERα and ERβ. Recent …
therapeutic targeting of androgen/estrogen receptor crosstalk in breast and prostate cancer. …

… non-NFκB targets and adverse toxic side effects [10]. Thus, safe and effective targeting of
the … Simultaneous targeting of ER and NFκB can be achieved by combination therapies that …

A strategy to develop chemotherapeutic agents by combining … efficacy compared to that of
single-target drugs. In this article, we … These novel hybrid compounds combine an indirect …