… response to antiestrogen therapy requires only measurement of ERα expression. The role
of altered receptor coactivator or corepressor expression in antiestrogen resistance also is …

… 47) and mutations (reviewed here) have been detected in various breast tumors, which might
have an impact on breast cancer development and susceptibility to antiestrogen treatment. …

… In multiple cell lines, Ser-118 is phosphorylated in response to various treatments,
including estrogens and antiestrogens, phorbol12-myristate 13-acetate [PMA, also known as …

… superior to other hormonal agents in the treatment of ovarian cancer, but that preselection
of … benefiting from anti-estrogen therapy. Unlike tamoxifen, letrozole is a pure anti-estrogen. …

… One can appreciate how the system is consolidated or amplified during long-term
antiestrogenic treatment because estrogen down-regulates HER2/neu synthesis by binding …

… to antiestrogen therapies, a high percentage of cases develop resistance to treatment over
… that result in constitutively active forms of the receptor in the metastatic-resistance stage of …

… Estrogen signaling plays a critical role in the pathogenesis of breast cancer. Because the …
carcinomas express the estrogen receptor ERα, endocrine therapy that impedes estrogen-ER …

… estrogen receptor-DNA binding by the 'pure' antiestrogen ICI 164,384 appears to be mediated
by impaired receptor … the hormone and antihormone estrogen receptor complexes bound …

… “antiestrogenic” medicines for the treatment and prevention of breast cancer. Developing drugs
that target the estrogen receptor (… The development of the principles for treatment and the …

… and anti-estrogen therapy is the gold standard of care in the treatment of estrogen receptor
(ER) … are several mysteries concerning both anti-estrogen, tamoxifen, and estrogen. The most …