Estrogen receptor mutations in human disease

MH Herynk, SAW Fuqua - Endocrine reviews, 2004 - academic.oup.com
… As early as the 1800s, the actions of estrogen have been implicated in the development
and progression of breast cancer. The estrogen receptor (ER) was identified in the late 1950s …

Estrogen receptor-β signaling modulates epithelial barrier function

M Looijer-van Langen, N Hotte… - American Journal …, 2011 - journals.physiology.org
estrogen or gender in IBD pathology remains inconclusive. Estrogen mediates its action via
estrogen receptors … Two estrogen receptors have been identified: estrogen receptor-α (ERα) …

Estradiol alters cell growth in nonmalignant colonocytes and reduces the formation of preneoplastic lesions in the colon

CC Weige, KF Allred, CD Allred - Cancer research, 2009 - AACR
colon by 71% (9). Orally administered estrone in ovariectomized wild-type (WT) and estrogen
receptor (… The Ki-Ras oncogene is present in ∼50% of colonic adenomas and carcinomas

The Triad of Estrogen, Estrogen Receptors, and Colon Cancer

KR Sumalatha, S Soumyakrishnan… - Colon Cancer Diagnosis …, 2022 - Springer
… effects of estrogen. Reduced expression of the nuclear estrogen receptor beta in the colon
is … In vitro studies on carcinoma cell lines and in vivo studies on mouse models have proven …

Prediction of Colorectal Neoplasia by Quantitative Methylation Analysis of Estrogen Receptor Gene in Nonneoplastic Epithelium from Patients with Ulcerative Colitis

K Tominaga, S Fujii, K Mukawa, M Fujita… - Clinical cancer …, 2005 - AACR
… The relationship between estrogen receptor gene methylation and inflammatory activity of
colitis. An examination of the inflammatory activity in the 46 samples from UC patients with …

Estrogen receptor β deficiency enhances small intestinal tumorigenesis in ApcMin/+ mice

V Giroux, F Lemay, G Bernatchez… - … journal of cancer, 2008 - Wiley Online Library
estradiol replacement therapy reduces colon cancer risk in ‘post’menopausal women. In colon
epithelial cells, the estrogen receptor … the genomic effect of estrogens. The first aim of this …

Expression, function, and clinical implications of the estrogen receptor β in human lung cancers

Y Omoto, Y Kobayashi, K Nishida, E Tsuchiya… - Biochemical and …, 2001 - Elsevier
… investigation of estrogen receptor (ER) … carcinomas. On the contrary, ERα expression was
not detected in all cases. The functional integrity of ERβ such as the binding ability to estrogen

Estrogen receptors in human nontarget tissues: biological and clinical implications

DR Ciocca, LM Vargas Roig - Endocrine reviews, 1995 - academic.oup.com
… in the study of estrogen receptor(s) (ER) and estrogen-regulated … not considered classic
targets for estrogens. The idea of … and estrogen receptor status on survival in gastric carcinoma

Estrogen receptors in colorectal cancer: goalkeepers, strikers, or bystanders?

J Hartman, JÅ Gustafsson - Cancer Prevention Research, 2010 - AACR
… ERβ is the only estrogen receptor in the normal colonic epithelium and declines dramatically
… ERβ is responsible for the protective effect of estrogens against colorectal carcinogenesis. …

Estrogenic induction of cannabinoid CB1 receptor in human colon cancer cell lines

M Notarnicola, C Messa, A Orlando… - Scandinavian journal …, 2008 - Taylor & Francis
… of estrogenic cell growth control in colon carcinoma, we investigated the effects of 17β-estradiol
exposure on CB1 receptor … after estradiol treatment could be a direct estrogen receptor-…