… we analyze the estrogen pathway as a possible therapeutic avenue in colorectal cancer, we
… molecular mechanisms of estrogen-mediated protection against colorectal tumorigenesis, …

… alter the structural organization and DNA binding of estrogen receptors in a dose-dependent
manner [… For example, estradiol binding to the receptor and the affinity of the ligand-receptor …

Colorectal cancer (CRC) is a leading cause of death in the United States. Despite its slow
development and the capacity for early diagnosis, current preventive approaches are not …

… colon cancer cells with ERβ gene constructed into adenoviral vectors alone or in combination
with raloxifene, a selective estrogen receptor … agent in HCT116 colon cancer cells by …

… Estrogens have been implicated in the pathogenesis of various cancer types, including
colorectal carcinoma (CRC). Estrogen receptors such as ERα and ERβ activate intracellular …

… Abnormal estrogen receptor signaling may increase the risk of development of a variety of
diseases including colorectal cancer (CRC). Estrogen receptor beta (ERβ) is the predominant …

… The estrogen receptor (ER) recognizes a molecule as estrogen based on its three-dimensional
configuration and charge, but preferentially binds E2 over E3 (2×) and E1 [3× (ref. 9)]…

… of estrogens on colon cancer risk. Given the scarcity of information regarding ER mRNA
expression levels in human colon… may mediate estrogenic effects on colon cancer susceptibility. …

… In conclusion, functional estrogen receptors are present in four distinct colon … of estrogens
on colorectal epithelial cancer cells. The simultaneous evaluation of multiple cell lines of colon …

… To investigate if the estrogen receptor ß detected by RT-PCR is functional in the colon
cancer cells, we transiently transfected Colo320 cells with a reporter plasmid containing three …