The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy

A Iorga, CM Cunningham, S Moazeni… - Biology of sex …, 2017 - Springer
… reproductive age is attributed at least in part to estrogen (E2). E2 binds to the traditional E2
receptors (ERs), estrogen receptor alpha (ERα), and estrogen receptor beta (ERβ), as well as …

Controversies surrounding estrogen use in postmenopausal women

DM Witt, TR Lousberg - Annals of Pharmacotherapy, 1997 - journals.sagepub.com
estrogen. The association between postmenopausal estrogen use and breast cancer remains
controversial, … This uncertainty regarding estrogen replacement and breast cancer risk can …

Selective estrogen receptor modulators: a controversial approach for managing postmenopausal health

MG CURTIS - Journal of Women's Health, 1999 - liebertpub.com
… act on the estrogen receptor, have been promoted for use as an alternative to hormonal …
properties of estrogen action. They are now referred to as selective estrogen receptor modu…

[PDF][PDF] Therapeutic controversy: estrogen replacement in menopause

R Lindsay, TL Bush, D Grady, L Speroff… - The Journal of Clinical …, 1996 - scholar.archive.org
… of estrogen receptors on bone cells (first osteoblasts and, more recently, some osteoclasts)
… no reductions in fracture risk associated with previous use of estrogen and only a modest (not …

[HTML][HTML] Estrogen, estrogen receptors, and hepatocellular carcinoma: Are we there yet?

OA Sukocheva - World journal of gastroenterology, 2018 - ncbi.nlm.nih.gov
… specific impact of estrogen receptor (ER) signalling in HCC are unclear and controversial. It
… Furthermore, the data received with the use of only one type of ERα-specific antibodies that …

A critical review of fundamental controversies in the field of GPR30 research

G Langer, B Bader, L Meoli, J Isensee, M Delbeck… - Steroids, 2010 - Elsevier
… Therefore, to clarify the role of GPR30 as an estrogen receptor, … the hypothesis of GPR30
acting as an estrogen receptor. … In addition, the use of saponin might change tertiary structures …

Estrogen receptors as therapeutic targets in breast cancer

EA Ariazi, JL Ariazi, F Cordera… - Current topics in …, 2006 - ingentaconnect.com
estrogen receptor α (ERα) has proven to be the single most important target in breast cancer
over the last 30 years. The use … in breast pathobiology remains controversial. The majority of …

Estrogen receptors in human nontarget tissues: biological and clinical implications

DR Ciocca, LM Vargas Roig - Endocrine reviews, 1995 - academic.oup.com
… Finally, a case-control study has reported that the use of estrogen replacement therapy is …
, and this has been a matter of controversy until the analytical methods were adapted to avoid …

Estrogen Receptor-β: Recent Lessons from in Vivo Studies

HA Harris - Molecular endocrinology, 2007 - academic.oup.com
… confer benefits on almost all organ systems and was prescribed clinically for long-term use.
… The role of estrogens in prostatic physiology is controversial. Historically, high doses of …

Selective estrogen receptor modulators in clinical practice: a safety overview

AJ Ellis, VM Hendrick, R Williams… - Expert opinion on drug …, 2015 - Taylor & Francis
… On November 20, 2014, the Committee for Medicinal Products for Human Use … that the
upper limit of normal thickness is controversial, and the appearance of endometrial thickening on …